Publication Name	World Journal of Gastroenterology
Manuscript ID	16076
Country	Canada

Received	2014-12-24 10:00
Peer-Review Started	2014-12-25 14:13
To Make the First Decision	2015-03-10 20:21
Return for Revision	2015-03-20 16:00
Revised
Second Decision	2015-06-10 09:16
Accepted by Journal Editor-in-Chief	2015-06-10 12:06
Accepted by Executive Editor-in-Chief	2015-06-16 11:17
Articles in Press	2015-06-16 11:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-27 11:09
Publish the Manuscript Online	2015-08-20 13:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Iron deficiency anemia in celiac disease
Manuscript Source	Invited Manuscript
All Author List	Hugh James Freeman
Funding Agency and Grant Number
Corresponding Author	Hugh Freeman, MD, CM, FRCPC, FACP, Professor, Department of Medicine (Gastroenterology), University of British Columbia, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada. hugfree@shaw.ca
Key Words	Anemia; Iron deficiency; Autoimmune hemolysis; Celiac disease; Iron absorption; Ferroportin; Hepcidin; Divalent metal transporter; Enterocyte
Core Tip	Iron is a critical micronutrient that may be deficient in well-established celiac disease or be the presenting clinical feature even in the absence of diarrhea or weight loss. Most often, impaired duodenal mucosal uptake of iron is evident since surface absorptive area in the duodenum in reduced, in large part, because celiac disease is an immune-mediated disorder largely focused in the proximal small intestine. Other superimposed small intestinal complications of celiac disease may be responsible causing blood loss, including ulceration or neoplasia. Finally, associated gastric or colonic causes of blood loss, immune-mediated hemolysis and reduced expression of different regulatory proteins critical in iron uptake may be present.
Publish Date	2015-08-20 13:37
Citation	Freeman HJ. Iron deficiency anemia in celiac disease. World J Gastroenterol 2015; 21(31): 9233-9238
URL	http://www.wjgnet.com/1007-9327/full/v21/i31/9233.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i31.9233

Full Article (PDF)	WJG-21-9233.pdf
Full Article (Word)	WJG-21-9233.doc
Manuscript File	16076-Review.doc
Answering Reviewers	16076-Answering reviewers.pdf
Audio Core Tip	16076-Audio core tip.wma
Conflict-of-Interest Disclosure Form	16076-Conflict-of-interest statement.pdf
Copyright License Agreement	16076-Copyright assignment.pdf
Peer-review Report	16076-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16076-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16076-Scientific misconduct check.pdf
Scientific Editor Work List	16076-Scientific editor work list.pdf