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Articles Published Processes
6/11/2015 10:11:00 AM | Browse: 1312 | Download: 2506
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Received |
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2014-12-26 09:31 |
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Peer-Review Started |
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2014-12-26 13:09 |
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To Make the First Decision |
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2015-01-22 16:48 |
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Return for Revision |
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2015-01-27 14:59 |
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Revised |
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Second Decision |
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2015-03-25 16:39 |
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Accepted by Journal Editor-in-Chief |
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2015-03-26 18:27 |
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Accepted by Executive Editor-in-Chief |
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2015-04-03 13:44 |
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Articles in Press |
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2015-04-03 13:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-04-17 16:05 |
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Typeset the Manuscript |
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2015-05-20 18:08 |
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Publish the Manuscript Online |
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2015-06-11 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Hepatitis B virus genotypes and genome characteristics in China
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Mei Li, Jian-Qiong Wang, Rui Wang, Qian Zhao, Li Li, Jin-Ping Zhang and Tao Shen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81160352 |
| Education Department Foundation of Yunnan Province |
2012J091 |
| Health Bureau of Yunnan Province |
D-201203 (partly) |
| Science and Technology Department of Yunnan Province |
2013HB084 (partly) |
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| Corresponding Author |
Dr. Tao Shen, Basic and Clinical Medicine Institute of Yunnan Province, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China. ts902@126.com |
| Key Words |
Hepatitis B virus; Genotype; Phylogenetic tree; Clinical symptoms; Mutation; Codon usage bias |
| Core Tip |
This study recapitulated the epidemiology of hepatitis B virus (HBV) in China. Genotype C was the predominant HBV genotype in Northeastern, genotype B was predominant in Central Southern areas, genotype B and C were both dominant in Southwestern areas, and the recombinant genotype C/D was predominant in Northwestern areas. C2 and B2 were identified as the two major subgenotypes, FJ386674 might be a putative sub-genotype as B10. Moreover, the termination codon usage bias of B2 (TAA) and C2 (TGA) subtype and the correlation between HBV sequence mutations and clinical symptoms were also determined. |
| Publish Date |
2015-06-11 10:11 |
| Citation |
Li HM, Wang JQ, Wang R, Zhao Q, Li L, Zhang JP, Shen T. Hepatitis B virus genotypes and genome characteristics in China. World J Gastroenterol 2015; 21(21): 6684-6697 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i21/6684.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i21.6684 |
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