Publication Name	World Journal of Gastroenterology
Manuscript ID	16097
Country	Japan

Received	2014-12-26 08:57
Peer-Review Started	2014-12-26 15:21
First Decision by Editorial Office Director
Return for Revision	2015-04-29 17:47
Revised	2015-05-14 23:05
Publication Fee Transferred
Second Decision by Editor	2015-06-03 08:52
Second Decision by Editor-in-Chief	2015-06-04 10:07
Final Decision by Editorial Office Director	2015-06-10 16:32
Articles in Press	2015-06-10 16:32
Edit the Manuscript by Language Editor	2015-07-08 18:55
Typeset the Manuscript	2015-07-31 11:29
Publish the Manuscript Online	2015-08-17 11:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Physiology
Manuscript Type	Basic Study
Article Title	Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions
Manuscript Source	Unsolicited Manuscript
All Author List	Yukihito Ishii, Yu Motohashi, Makoto Muramatsu, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Takahisa Yamada, Tohru Matsui, Shinichi Kume and Takeshi Ohta
Funding Agency and Grant Number
Corresponding Author	Yukihito Ishii, PhD, Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan. yukihito.ishii@jt.com
Key Words	Nonalcoholic steatohepatitis; Spontaneously diabetic Torii fatty rat; Fibrosis; Fatty liver; Metabolic syndrome
Core Tip	Nonalcoholic steatohepatitis (NASH) is recognized as a major risk for progression to cirrhosis and liver failure or to hepatocellular carcinoma. In this study, we investigated the histological features of the liver in female spontaneously diabetic Torii (SDT) fatty rats. The SDT fatty rats exhibited pathophysiological features of NASH, and fibrosis appeared in the liver without dietary manipulation. Female SDT fatty rats have the potential to become an important animal model of NASH with type 2 diabetes and obesity, a condition for which few models currently exist.
Publish Date	2015-08-17 11:15
Citation	Ishii Y, Motohashi Y, Muramatsu M, Katsuda Y, Miyajima K, Sasase T, Yamada T, Matsui T, Kume S, Ohta T. Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions. World J Gastroenterol 2015; 21(30): 9067-9078
URL	http://www.wjgnet.com/1007-9327/full/v21/i30/9067.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i30.9067

Full Article (PDF)	WJG-21-9067.pdf
Full Article (Word)	WJG-21-9067.doc