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Articles Published Processes
7/14/2015 12:17:00 PM | Browse: 1055 | Download: 2553
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Received |
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2014-12-27 13:22 |
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Peer-Review Started |
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2014-12-27 15:02 |
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To Make the First Decision |
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2015-01-22 16:47 |
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Return for Revision |
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2015-01-26 20:19 |
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Revised |
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2015-04-01 14:14 |
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Second Decision |
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2015-05-13 07:31 |
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Accepted by Journal Editor-in-Chief |
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2015-05-13 11:23 |
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Accepted by Executive Editor-in-Chief |
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2015-05-21 17:19 |
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Articles in Press |
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2015-05-21 17:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-06-01 21:14 |
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Typeset the Manuscript |
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2015-06-30 17:39 |
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Publish the Manuscript Online |
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2015-07-14 12:17 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Conjugation of toll-like receptor-7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Dong Wang, Ning-Ning Gao, Yu-Wen Diao, Yu Liu, Dong Gao, Wang Li, Yan-Yan Wan, Jing-Jing Zhong and Guang-Yi Jin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81202396 |
| National Natural Science Foundation of China |
81273374 |
| Science Foundation of Shenzhen |
JCYJ20130326112757843 |
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| Corresponding Author |
Guang-Yi Jin, PhD, Professor of Medicinal Chemistry, School of Medicine, Shenzhen University, No. 3688 Nanhai Avenue, Shenzhen 518060, Guangdong Province, China. gyjin@szu.edu.cn |
| Key Words |
Gastric cancer; Immunotherapy; Monoclonal gastric cancer 7 antigen; Toll-like receptor-7; Vaccine |
| Core Tip |
Immunization with toll-like receptor-7 agonist conjugated with a monoclonal gastric cancer 7 antigen tri-epitope was efficacious in reversing tolerance and generating a therapeutic response in Ehrlich ascites carcinoma tumor-bearing mice. This occurred by enhancing the specific humoral and cellular immunity, which were displayed as higher antibody titers, antibody-dependent cell-mediated cytotoxicity, and cytotoxic T lymphocyte activity. |
| Publish Date |
2015-07-14 12:17 |
| Citation |
Wang XD, Gao NN, Diao YW, Liu Y, Gao D, Li W, Wan YY, Zhong JJ, Jin GY. Conjugation of toll-like receptor-7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects. World J Gastroenterol 2015; 21(26): 8052-8060 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i26/8052.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i26.8052 |
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