Publication Name	World Journal of Gastroenterology
Manuscript ID	16134
Country	Czech Republic

Received	2014-12-28 17:51
Peer-Review Started	2014-12-29 14:50
To Make the First Decision	2015-01-22 16:47
Return for Revision	2015-01-26 19:13
Revised	2015-02-06 18:39
Second Decision	2015-03-29 10:07
Accepted by Journal Editor-in-Chief	2015-03-29 14:51
Accepted by Executive Editor-in-Chief	2015-04-03 13:45
Articles in Press	2015-04-03 13:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-06 08:57
Typeset the Manuscript	2015-05-29 19:42
Publish the Manuscript Online	2015-06-18 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Systematic Reviews
Article Title	Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go?
Manuscript Source	Unsolicited Manuscript
All Author List	Peter Ihnát, Petr Vávra and Pavel Zonča
Funding Agency and Grant Number
Corresponding Author	Peter Ihnát, MD, PhD, MBA, Department of Surgical Studies, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava 70300, Czech Republic. peterihnat@yahoo.com
Key Words	Colorectal cancer; Liver-first approach; Reverse strategy; Simultaneous resection; Up-front hepatectomy
Core Tip	There are four treatment strategies available for synchronous liver metastases of colorectal carcinoma (CLM): (1) primary first approach comprises resection of the primary colorectal tumor followed by chemotherapy and liver resection; (2) simultaneous resection of liver and colorectal primary tumor; (3) liver-first (or chemotherapy-first) approach comprises preoperative chemotherapy, liver resection, adjuvant chemotherapy, and resection of the primary colorectal tumor (best for asymptomatic primary tumors and initially unresectable or marginally resectable CLM); and (4) up-front hepatectomy (or “true” liver-first approach) includes liver resection followed by adjuvant chemotherapy and colorectal resection (for asymptomatic primary tumors and initially resectable CLM).
Publish Date	2015-06-18 17:32
Citation	Ihnát P, Vávra P, Zonča P. Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go? World J Gastroenterol 2015; 21(22): 7014-7021
URL	http://www.wjgnet.com/1007-9327/full/v21/i22/7014.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i22.7014

Full Article (PDF)	WJG-21-7014.pdf
Full Article (Word)	WJG-21-7014.doc
Manuscript File	16134-Review.doc
Answering Reviewers	16134-Answering reviewers.pdf
Audio Core Tip	16134-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16134-Conflict-of-interest statement.pdf
Copyright License Agreement	16134-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	16134-Language certificate.pdf
Peer-review Report	16134-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16134-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16134-Scientific misconduct check.pdf
Scientific Editor Work List	16134-Scientific editor work list.pdf