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12/2/2015 11:52:00 AM | Browse: 351 | Download: 382
Publication Name World Journal of Clinical Cases
Manuscript ID 16143
Country/Territory
Received
2014-12-29 19:09
Peer-Review Started
2014-12-30 08:26
To Make the First Decision
2015-02-07 15:01
Return for Revision
2015-02-11 15:32
Revised
2015-03-02 01:11
Second Decision
2015-04-26 20:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-05-06 14:16
Articles in Press
2015-05-06 14:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-07-07 19:04
Publish the Manuscript Online
2015-07-27 18:31
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Clinical Neurology
Manuscript Type Review
Article Title Treatment strategies for multiple sclerosis: When to start, when to change, when to stop?
Manuscript Source Invited Manuscript
All Author List Alberto Gajofatto and Maria Donata Benedetti
Funding Agency and Grant Number
Corresponding author Alberto Gajofatto, MD, PhD, Department of Neurological and Movement Sciences, University of Verona, Policlinico G. Rossi, Piazzale Scuro 9, 37134 Verona, Italy. alberto.gajofatto@univr.it
Keywords Multiple sclerosis; Disease-modifying therapy; Treatment start; Treatment switch; Treatment stop; Interferon beta; Glatiramer acetate; Azathioprine; Natalizumab; Fingolimod
Core Tip Disease-modifying therapies for multiple sclerosis (MS) modulate or suppress with different mechanisms the autoimmune process that underlies the disease. Patients with relapsing MS may benefit from treatment but individual response to a given therapy and adverse events occurrence are largely unpredictable and many cases need to change several drugs to stabi-lize their disease. Nevertheless, a high proportion of patients evolve to a progressive phase, which is not responsive to any existing therapy. As opposed, some cases have a benign course without treatment. A critical review of strategies for starting, switching and stopping disease-modifying therapies for MS is here presented.
Publish Date 2015-07-27 18:31
Citation Gajofatto A, Benedetti MD. Treatment strategies for multiple sclerosis: When to start, when to change, when to stop? World J Clin Cases 2015; 3(7): 545-555
Url http://www.wjgnet.com/2307-8960/full/v3/i7/545.htm
DOI http://dx.doi.org/10.12998/wjcc.v3.i7.545
Full Article (PDF) WJCC-3-545.pdf
Full Article (Word) WJCC-3-545.doc
Manuscript File 16143-Review.doc
Answering Reviewers 16143-Answering reviewers.pdf
Audio Core Tip 16143-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16143-Conflict-of-interest statement.pdf
Copyright License Agreement 16143-Copyright assignment.pdf
Peer-review Report 16143-Peer-review(s).pdf
Scientific Misconduct Check 16143-Scientific misconduct check.pdf
Scientific Editor Work List 16143-Scientific editor work list.pdf