Publication Name	World Journal of Clinical Cases
Manuscript ID	16143
Country

Received	2014-12-29 19:09
Peer-Review Started	2014-12-30 08:26
To Make the First Decision	2015-02-07 15:01
Return for Revision	2015-02-11 15:32
Revised	2015-03-02 01:11
Second Decision	2015-04-26 20:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-05-06 14:16
Articles in Press	2015-05-06 14:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-07 19:04
Publish the Manuscript Online	2015-07-27 18:31

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Clinical Neurology
Manuscript Type	Review
Article Title	Treatment strategies for multiple sclerosis: When to start, when to change, when to stop?
Manuscript Source	Invited Manuscript
All Author List	Alberto Gajofatto and Maria Donata Benedetti
Funding Agency and Grant Number
Corresponding Author	Alberto Gajofatto, MD, PhD, Department of Neurological and Movement Sciences, University of Verona, Policlinico G. Rossi, Piazzale Scuro 9, 37134 Verona, Italy. alberto.gajofatto@univr.it
Key Words	Multiple sclerosis; Disease-modifying therapy; Treatment start; Treatment switch; Treatment stop; Interferon beta; Glatiramer acetate; Azathioprine; Natalizumab; Fingolimod
Core Tip	Disease-modifying therapies for multiple sclerosis (MS) modulate or suppress with different mechanisms the autoimmune process that underlies the disease. Patients with relapsing MS may benefit from treatment but individual response to a given therapy and adverse events occurrence are largely unpredictable and many cases need to change several drugs to stabi-lize their disease. Nevertheless, a high proportion of patients evolve to a progressive phase, which is not responsive to any existing therapy. As opposed, some cases have a benign course without treatment. A critical review of strategies for starting, switching and stopping disease-modifying therapies for MS is here presented.
Publish Date	2015-07-27 18:31
Citation	Gajofatto A, Benedetti MD. Treatment strategies for multiple sclerosis: When to start, when to change, when to stop? World J Clin Cases 2015; 3(7): 545-555
URL	http://www.wjgnet.com/2307-8960/full/v3/i7/545.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i7.545

Full Article (PDF)	WJCC-3-545.pdf
Full Article (Word)	WJCC-3-545.doc
Manuscript File	16143-Review.doc
Answering Reviewers	16143-Answering reviewers.pdf
Audio Core Tip	16143-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16143-Conflict-of-interest statement.pdf
Copyright License Agreement	16143-Copyright assignment.pdf
Peer-review Report	16143-Peer-review(s).pdf
Scientific Misconduct Check	16143-Scientific misconduct check.pdf
Scientific Editor Work List	16143-Scientific editor work list.pdf