Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	16171
Country	United States

Received	2014-12-31 17:31
Peer-Review Started	2015-01-01 16:36
To Make the First Decision	2015-01-20 13:28
Return for Revision	2015-01-20 17:23
Revised	2015-01-31 07:33
Second Decision	2015-04-24 18:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-05-06 14:09
Articles in Press	2015-05-06 14:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-30 14:32
Publish the Manuscript Online	2015-07-14 18:49

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Endoscopic botox injections in therapy of refractory gastroparesis
Manuscript Source	Invited Manuscript
All Author List	Andrew Ukleja, Kanwarpreet Tandon, Kinchit Shah and Alicia Alvarez
Funding Agency and Grant Number
Corresponding Author	Andrew Ukleja, MD, Department of Gastroenterology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, United States. uklejaa@ccf.org
Key Words	Gastroparesis; Delayed gastric emptying; Botox; Botulinum toxin; Refractory gastroparesis
Core Tip	Refractory gastroparesis (GP) has been iden-tified as a chronic debilitating disease. After failure of diet and prokinetic drugs for treatment of refrac-tory GP only surgical options are left. Beca-use of the limited available treatment options and frequent failure of medical therapy, botulinum toxin (BT) injection in the pylorus might offer clinical value in GP. Currently available evidence is not strong enough to support the recommendation of this procedure in all patients with refractory GP; but promising results have been seen as most patients have noticed symptomatic improvement. Although BT injections were successful in some GP patients, the role of BT remains undetermined. We addressed the position of botulinum toxin in the spec-trum of available treatments for refractory GP. Conti-nuing other treatment modalities after BT may improve the results.
Publish Date	2015-07-14 18:49
Citation	Ukleja A, Tandon K, Shah K, Alvarez A. Endoscopic botox injections in therapy of refractory gastroparesis. World J Gastrointest Endosc 2015; 7(8): 790-798
URL	http://www.wjgnet.com/1948-5190/full/v7/i8/790.htm
DOI	http://dx.doi.org/10.4253/wjge.v7.i8.790

Full Article (PDF)	WJGE-7-790.pdf
Full Article (Word)	WJGE-7-790.doc
Manuscript File	16171-Review.docx
Answering Reviewers	16171-Answering reviewers.pdf
Audio Core Tip	16171-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16171-Conflict-of-interest statement.pdf
Copyright License Agreement	16171-Copyright assignment.pdf
Peer-review Report	16171-Peer-review(s).pdf
Scientific Misconduct Check	16171-Scientific misconduct check.pdf
Scientific Editor Work List	16171-Scientific editor work list.pdf