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Articles Published Processes
8/8/2015 3:25:00 PM | Browse: 1076 | Download: 2444
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Received |
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2015-01-03 15:36 |
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Peer-Review Started |
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2015-01-03 17:15 |
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To Make the First Decision |
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2015-01-22 16:35 |
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Return for Revision |
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2015-02-03 07:53 |
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Revised |
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2015-02-14 22:14 |
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Second Decision |
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2015-03-23 08:13 |
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Accepted by Journal Editor-in-Chief |
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2015-03-23 14:35 |
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Accepted by Executive Editor-in-Chief |
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2015-03-27 17:57 |
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Articles in Press |
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2015-03-27 18:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-04-08 10:57 |
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Typeset the Manuscript |
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2015-07-13 21:38 |
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Publish the Manuscript Online |
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2015-08-08 15:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Upregulation of nemo-like kinase is an independent prognostic factor in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Zhang, Jian He, Yan Du, Xian-Hua Gao, Yan Liu, Qi-Zhi Liu, Wen-Jun Chang, Guang-Wen Cao and Chuan-Gang Fu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81272670 |
| National Natural Science Foundation of China |
81201936 |
| National Natural Science Foundation of China |
81025015 |
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| Corresponding Author |
Chuan-Gang Fu, MD, PhD, Professor, Department of Colorectal Surgery, Changhai Hospital, The Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China. fugang416@126.com |
| Key Words |
Colorectal cancer; Gene regulation; Nemo-like kinase; Prognosis |
| Core Tip |
Altered expression of nemo-like kinase (NLK) protein is associated with cancer development. This study systematically evaluated NLK expression in different stages of colorectal cancer (CRC) for association with CRC prognosis. NLK expression progressively increased from normal tissues through adenoma, stage Ⅰ, Ⅱ, and Ⅲ, to stage Ⅳ CRC. However, knockdown of NLK expression significantly inhibited CRC cell growth, migration, cell cycle progression, and matrix metalloproteinase-2 expression. These data demonstrate that NLK overexpression is an independent CRC prognostic indicator and that knockdown of NLK expression inhibits CRC cell progression and metastasis. |
| Publish Date |
2015-08-08 15:26 |
| Citation |
Zhang W, He J, Du Y, Gao XH, Liu Y, Liu QZ, Chang WJ, Cao GW, Fu CG. Upregulation of nemo-like kinase is an independent prognostic factor in colorectal cancer. World J Gastroenterol 2015; 21(29): 8836-8847 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i29/8836.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i29.8836 |
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