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6/20/2015 5:38:00 PM | Browse: 675 | Download: 1077
Publication Name World Journal of Gastroenterology
Manuscript ID 16205
Country/Territory China
2015-01-04 10:19
Peer-Review Started
2015-01-05 08:36
To Make the First Decision
2015-01-22 16:22
Return for Revision
2015-02-03 07:54
2015-02-13 11:30
Second Decision
2015-04-07 17:03
Accepted by Journal Editor-in-Chief
2015-04-08 07:21
Accepted by Company Editor-in-Chief
2015-04-09 17:03
Articles in Press
2015-04-09 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-05-08 13:29
Typeset the Manuscript
2015-06-05 11:48
Publish the Manuscript Online
2015-06-20 17:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats
Manuscript Source Unsolicited Manuscript
All Author List Yong-Zhan Zhen, Na-Ren Li, Hong-Wei He, Shuang-Shuang Zhao, Guang-Ling Zhang, Xiao-Fang Hao and Rong-Guang Shao
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81170409
National Natural Science Foundation of China 81201281
National S&T Major Special Project on Major New Drug Innovation 2012ZX09301002
Wang Bao En Liver Fibrosis Foundation 20110026
Corresponding Author Hong-Wei He, Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9, Dongdan san tiao, Dongcheng District, Beijing 100050, China. hehwei@imb.pumc.edu.cn
Key Words Bicyclol; Rat; Bile duct ligation; Liver fibrosis; Gene expression profile
Core Tip Cholestasis often fails to respond to medical therapy, resulting in liver necrosis, fibrosis, cirrhosis, and subsequent liver failure. Bicyclol has significant liver protective effects, but little is known about the effect of this drug on cholestatic liver fibrosis. Therefore, the present study was designed to investigate the protective effects of bicyclol in a rat model of liver fibrosis induced by bile duct ligation (BDL). Bicyclol can improve liver function after BDL and decrease bile duct proliferation, inflammation and fibrosis. Bicyclol might be an effective anti-fibrotic drug for the treatment of cholestatic liver disease.
Publish Date 2015-06-20 17:38
Citation Zhen YZ, Li NR, He HW, Zhao SS, Zhang GL, Hao XF, Shao RG. Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats. World J Gastroenterol 2015; 21(23): 7155-7164
URL http://www.wjgnet.com/1007-9327/full/v21/i23/7155.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i23.7155
Full Article (PDF) WJG-21-7155.pdf
Full Article (Word) WJG-21-7155.doc
Manuscript File 16205-Review.doc
Answering Reviewers 16205-Answering reviewers.pdf
Biostatistics Review Certificate 16205-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 16205-Conflict-of-interest statement.pdf
Copyright License Agreement 16205-Copyright assignment.pdf
Data Sharing Statement 16205-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 16205-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 16205-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 16205-Language certificate.pdf
Peer-review Report 16205-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16205-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16205-Scientific misconduct check.pdf
Scientific Editor Work List 16205-Scientific editor work list.pdf