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Articles Published Processes
6/20/2015 5:38:00 PM | Browse: 1288 | Download: 2076
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Received |
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2015-01-04 10:19 |
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Peer-Review Started |
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2015-01-05 08:36 |
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To Make the First Decision |
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2015-01-22 16:22 |
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Return for Revision |
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2015-02-03 07:54 |
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Revised |
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2015-02-13 11:30 |
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Second Decision |
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2015-04-07 17:03 |
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Accepted by Journal Editor-in-Chief |
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2015-04-08 07:21 |
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Accepted by Executive Editor-in-Chief |
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2015-04-09 17:03 |
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Articles in Press |
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2015-04-09 17:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-05-08 13:29 |
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Typeset the Manuscript |
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2015-06-05 11:48 |
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Publish the Manuscript Online |
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2015-06-20 17:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong-Zhan Zhen, Na-Ren Li, Hong-Wei He, Shuang-Shuang Zhao, Guang-Ling Zhang, Xiao-Fang Hao and Rong-Guang Shao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81170409 |
| National Natural Science Foundation of China |
81201281 |
| National S&T Major Special Project on Major New Drug Innovation |
2012ZX09301002 |
| Wang Bao En Liver Fibrosis Foundation |
20110026 |
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| Corresponding Author |
Hong-Wei He, Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9, Dongdan san tiao, Dongcheng District, Beijing 100050, China. hehwei@imb.pumc.edu.cn |
| Key Words |
Bicyclol; Rat; Bile duct ligation; Liver fibrosis; Gene expression profile |
| Core Tip |
Cholestasis often fails to respond to medical therapy, resulting in liver necrosis, fibrosis, cirrhosis, and subsequent liver failure. Bicyclol has significant liver protective effects, but little is known about the effect of this drug on cholestatic liver fibrosis. Therefore, the present study was designed to investigate the protective effects of bicyclol in a rat model of liver fibrosis induced by bile duct ligation (BDL). Bicyclol can improve liver function after BDL and decrease bile duct proliferation, inflammation and fibrosis. Bicyclol might be an effective anti-fibrotic drug for the treatment of cholestatic liver disease. |
| Publish Date |
2015-06-20 17:38 |
| Citation |
Zhen YZ, Li NR, He HW, Zhao SS, Zhang GL, Hao XF, Shao RG. Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats. World J Gastroenterol 2015; 21(23): 7155-7164 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i23/7155.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i23.7155 |
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