Publication Name	World Journal of Gastroenterology
Manuscript ID	1621
Country	China

Received	2012-12-24 10:32
Peer-Review Started	2012-12-24 16:52
To Make the First Decision	2013-01-09 15:53
Return for Revision	2013-01-16 15:48
Revised	2013-02-04 11:13
Second Decision	2013-04-03 15:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-04 04:01
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-03 14:22
Publish the Manuscript Online	2013-06-14 23:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Human liver tissue metabolic profiling research on hepatitis B virus-related hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Shu-Ye Liu, Rikki-Lei Zhang, Hua Kang, Zhi-Juan Fan and Zhi Du
Funding Agency and Grant Number
Corresponding Author	Zhi Du, MD, Department of Hepatobiliary Surgery, Tianjin Third Central Hospital, No. 83 Jintang Road, Hedong District, Tianjin 300170, China. graylion@163.com
Key Words	Hepatocellular carcinoma; Metabolomics; Characteristic metabolites; Potential biomarker; Ultra performance liquid chromatography-mass spectrometry
Core Tip	An ultra performance liquid chromatography-mass spectrometry platform was used in the present study to identify characteristic metabolites in hepatitis B virus-related hepatocellular carcinoma tumor tissues. From an orthogonal partial least squares discriminant analysis model established to determine metabolic profiling in the central tumor tissue group, adjacent tissue group and distant tissue group, 49 ions were selected and 14 of these were identified as characteristic metabolites. The detection of these metabolites in tumor tissue not only confirmed the targeted traceability of previously reported serum biomarkers related to cancer diagnosis, but also provided novel targets for anticancer research.
Publish Date	2013-06-14 23:10
Citation	Liu SY, Zhang RL, Kang H, Fan ZJ, Du Z. Human liver tissue metabolic profiling research on hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2013; 19(22): 3423-3432
URL	http://www.wjgnet.com/1007-9327/full/v19/i22/3423.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i22.3423

Full Article (PDF)	WJG-19-3423.pdf
Manuscript File	1621-Review.doc
Answering Reviewers	1621-Answering reviewers.doc
Copyright License Agreement	1621-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1621-Language certificate.doc
Peer-review Report	1621-Peer review(s).pdf
Scientific Editor Work List	1621-Scientific editor work list.doc