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Articles Published Processes
7/8/2015 12:00:00 PM | Browse: 1042 | Download: 2926
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Received |
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2015-01-06 09:45 |
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Peer-Review Started |
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2015-01-06 16:09 |
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To Make the First Decision |
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2015-01-22 16:41 |
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Return for Revision |
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2015-02-02 08:05 |
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Revised |
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2015-02-14 10:23 |
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Second Decision |
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2015-03-25 16:56 |
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Accepted by Journal Editor-in-Chief |
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2015-03-26 07:13 |
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Accepted by Executive Editor-in-Chief |
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2015-03-31 09:56 |
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Articles in Press |
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2015-03-31 11:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-04-30 18:59 |
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Typeset the Manuscript |
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2015-06-23 11:40 |
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Publish the Manuscript Online |
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2015-07-08 12:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shu-Jun Jiang, Hui Dong, Jing-Bin Li, Li-Jun Xu, Xin Zou, Kai-Fu Wang, Fu-Er Lu and Ping Yi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30973836 |
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| Corresponding Author |
Ping Yi, PhD, Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. pyi219@163.com |
| Key Words |
Berberine; Diabetes; AMPK; Hepatic gluconeogenesis; LKB1; TORC2 |
| Core Tip |
We showed that liver kinase (LK)B1 acts as the upstream regulator of AMP-activated protein kinase (AMPK) and participates in gluconeogenesis. AMPK phosphorylation triggers CREB-regulated transcription co-activator (TORC)2 phosphorylation, which results in the inhibition of the nuclear translocation of TORC2. Thus, gluconeogenesis is restrained. No previous studies have reported the molecular mechanisms of berberine reducing hyperglycemia via the inhibition of hepatic gluconeogenesis. We found that berberine upregulated protein expression of LKB1, AMPK, p-AMPK and p-TORC2. Moreover, we observed that berberine inhibited the translocation of TOCR2 into the cell nucleus. |
| Publish Date |
2015-07-08 12:01 |
| Citation |
Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P. Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World J Gastroenterol 2015; 21(25): 7777-7785 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i25/7777.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i25.7777 |
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