Publication Name	World Journal of Gastroenterology
Manuscript ID	16245
Country	China

Received	2015-01-06 14:32
Peer-Review Started	2015-01-06 14:42
To Make the First Decision	2015-02-10 15:54
Return for Revision	2015-02-13 11:10
Revised	2015-02-26 19:32
Second Decision	2015-03-25 16:58
Accepted by Journal Editor-in-Chief	2015-03-27 23:36
Accepted by Executive Editor-in-Chief	2015-04-17 16:22
Articles in Press	2015-04-17 16:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-04-29 17:30
Typeset the Manuscript	2015-06-05 14:52
Publish the Manuscript Online	2015-06-20 17:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effects of electroacupuncture on corticotropin-releasing hormone expression in the colon target organ and central nervous system of rats with chronic visceral hypersensitivity
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Rong Liu, Xiao-Yi Fang, Huan-Gan Wu, Lu-Yi Wu, Jing Li, Zhi-Jun Weng, Xin-Xin Guo and Yu-Guang Li
Funding Agency and Grant Number	Funding Agency Grant Number China Postdoctoral Science Foundation 200801260 China Postdoctoral Science Foundation 20080430117 National Basic Research Program of China（973 Program） 2009CB522900 Specialized Research Fund for the Doctoral Program of Higher Education 20123107110008
Corresponding Author	Yu-Guang Li, PhD, Professor, First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou 515041, Guangdong Province, China. yglee317@126.com
Key Words	Corticotropin-releasing hormone; Electroacupuncture; Irritable bowel syndrome; Visceral pain; Shangjuxu
Core Tip	Visceral hypersensitivity is enhanced in irritable bowel syndrome (IBS) rats. Electroacupuncture at Shangjuxu can significantly reduce the visceral hypersensitivity to colorectal distension in IBS rats, with a reduced pain threshold being observed. The expression of corticotropin-releasing hormone (CRH) protein and mRNA in the target organ and central nervous system of these rats is abnormal to varying degrees, and electroacupuncture at Shangjuxu can regulate the expression of CRH protein and mRNA in the target organ (colon) and central nervous system (spinal cord and hypothalamus) at different levels, exerting a therapeutic effect on the visceral hypersensitivity of IBS rats.
Publish Date	2015-06-20 17:38
Citation	Liu HR, Fang XY, Wu HG, Wu LY, Li J, Weng ZJ, Guo XX, Li YG. Effects of electroacupuncture on corticotropin-releasing hormone in rats with chronic visceral hypersensitivity. World J Gastroenterol 2015; 21(23): 7181-7190
URL	http://www.wjgnet.com/1007-9327/full/v21/i23/7181.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i23.7181

Full Article (PDF)	WJG-21-7181.pdf
Full Article (Word)	WJG-21-7181.doc
Manuscript File	16245-Review.doc
Answering Reviewers	16245-Answering reviewers.pdf
Audio Core Tip	16245-Audio core tip.mp3
Biostatistics Review Certificate	16245-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16245-Conflict-of-interest statement.pdf
Copyright License Agreement	16245-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	16245-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	16245-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	16245-Language certificate.pdf
Peer-review Report	16245-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16245-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16245-Scientific misconduct check.pdf
Scientific Editor Work List	16245-Scientific editor work list.pdf