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Articles Published Processes
6/29/2015 4:40:00 PM | Browse: 992 | Download: 2041
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Received |
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2015-01-07 08:49 |
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Peer-Review Started |
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2015-01-07 16:20 |
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To Make the First Decision |
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2015-01-22 16:41 |
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Return for Revision |
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2015-02-02 08:05 |
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Revised |
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2015-02-26 09:19 |
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Second Decision |
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2015-03-29 10:06 |
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Accepted by Journal Editor-in-Chief |
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2015-03-29 15:30 |
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Accepted by Executive Editor-in-Chief |
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2015-04-03 14:22 |
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Articles in Press |
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2015-04-03 14:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-04-20 06:10 |
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Typeset the Manuscript |
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2015-06-12 11:09 |
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Publish the Manuscript Online |
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2015-06-29 16:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Grape seed proanthocyanidin protects liver against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Chao Xu, Jie Yin, Bo Zhou, Yu-Ting Liu, Yue Yu and Guo-Qiang Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jiangsu Province Natural Science Fund Subject |
BK20131445 |
| Scientific Research Program of Ministry of Health |
201302009 |
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| Corresponding Author |
Guo-Qiang Li, MD, PhD, Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. liguoqiang@njmu.edu.cn |
| Key Words |
Anti-apoptosis; Endoplasmic reticulum stress; Grape seed proanthocyanidin; Inflammation; Ischemia/reperfusion injury |
| Core Tip |
Liver ischemia/reperfusion (IR) injury induces endoplasmic reticulum (ER) stress. Numerous studies show that excessive ER stress aggravates IR injury. Grape seed proanthocyanidin (GSP) is an effective protector against IR injury. However, the detailed protective mechanisms remain unclear. Therefore, this study explored the effect of GSP in the liver for protection against IR injury and the alleviation of ER stress. The results indicate that GSP possesses antioxidative, anti-inflammatory, and antiapoptotic effects by relieving ER stress in the liver through regulation of related signaling pathways. |
| Publish Date |
2015-06-29 16:33 |
| Citation |
Xu ZC, Yin J, Zhou B, Liu YT, Yu Y, Li GQ. Grape seed proanthocyanidin protects liver against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress. World J Gastroenterol 2015; 21(24): 7468-7477 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i24/7468.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i24.7468 |
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