Publication Name	World Journal of Orthopedics
Manuscript ID	16263
Country	United States

Received	2015-01-07 08:32
Peer-Review Started	2015-01-07 19:58
To Make the First Decision	2015-02-07 14:46
Return for Revision	2015-02-12 10:58
Revised	2015-02-24 12:59
Second Decision	2015-06-08 11:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-06-16 16:49
Articles in Press	2015-06-16 16:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-31 12:27
Publish the Manuscript Online	2015-08-20 08:24

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Prospective Study
Article Title	Can tranexamic acid change preoperative anemia management during total joint arthroplasty?
Manuscript Source	Unsolicited Manuscript
All Author List	Duy L Phan, Joseph B Rinehart and Ran Schwarzkopf
Funding Agency and Grant Number
Corresponding Author	Duy L Phan, MD, Department of Orthopaedic Surgery, University of California, 101 The City Drive South, Irvine, CA 92868, United States. phandl@uci.edu
Key Words	Total knee replacement; Tranexamic acid; Total hip replacement; Preoperative anemia
Core Tip	Patients with preoperative anemia presenting for total joint arthroplasty (TJA) have an increased risk of requiring allogeneic blood transfusion (ABT). Current methods to increase preoperative hemoglobin is expensive, limited in efficacy, and have side effects. In this study, we found that intraoperative tranexamic acid (TXA) safely and effectively decreases blood loss and limits the rate of ABT after TJA for anemic patients. We recommend TXA for all patients without contraindications who have preoperative anemia.
Publish Date	2015-08-20 08:24
Citation	Phan DL, Rinehart JB, Schwarzkopf R. Can tranexamic acid change preoperative anemia management during total joint arthroplasty? World J Orthop 2015; 6(7): 521-527
URL	http://www.wjgnet.com/2218-5836/full/v6/i7/521.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i7.521

Full Article (PDF)	WJO-6-521.pdf
Full Article (Word)	WJO-6-521.doc
Manuscript File	16263-Review.docx
Answering Reviewers	16263-Answering reviewers.pdf
Audio Core Tip	16263-Audio core tip.mp3
Biostatistics Review Certificate	16263-Biostatistics statement.pdf
Clinical Trial Registration Statement	16263-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	16263-Conflict-of-interest statement.pdf
Copyright License Agreement	16263-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	16263-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	16263-Institutional review board statement.pdf
Peer-review Report	16263-Peer-review(s).pdf
Scientific Misconduct Check	16263-Scientific misconduct check.pdf
Scientific Editor Work List	16263-Scientific editor work list.pdf