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6/11/2015 10:11:00 AM | Browse: 1352 | Download: 1927
Publication Name World Journal of Gastroenterology
Manuscript ID 16283
Country/Territory Canada
Received
2015-01-08 08:32
Peer-Review Started
2015-01-08 16:32
To Make the First Decision
2015-01-22 16:40
Return for Revision
2015-02-02 08:09
Revised
2015-02-11 05:32
Second Decision
2015-03-09 14:32
Accepted by Journal Editor-in-Chief
2015-03-12 21:29
Accepted by Company Editor-in-Chief
2015-03-19 16:57
Articles in Press
2015-03-19 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-05-21 17:08
Publish the Manuscript Online
2015-06-11 10:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Allergy
Manuscript Type Case Control Study
Article Title Pancreatic cancer serum biomarker PC-594: Diagnostic performance and comparison to CA19-9
Manuscript Source Unsolicited Manuscript
All Author List Shawn A Ritchie, Bassirou Chitou, Qingan Zheng, Dushmanthi Jayasinghe, Wei Jin, Asuka Mochizuki and Dayan B Goodenowe
Funding Agency and Grant Number
Corresponding Author Dr. Shawn A Ritchie, Department of Biomarker Discovery and Validation, Phenomenome Discoveries, Inc. 204-407 Downey Road, Saskatoon, SK S7N 4L8, Canada. s.ritchie@phenomenome.com
Key Words Pancreatic cancer; Risk; Screening; Blood; Fatty acid; Biomarker; Metabolite; PC-594
Core Tip The incidence of pancreatic cancer (PaC) in the general population is too low to warrant screening by imaging or endoscopic ultrasound. In this paper, we provide further validation that the serum fatty acid metabolite PC-594 is a viable PaC biomarker by showing that it is significantly reduced in North American PaC patients compared to control subjects, and that its performance is superior to CA19-9. This reduction represents a near 10-fold increase for PaC risk, and a PaC incidence among PC-594 deficient subjects that exceeds the incidence of colorectal cancer considered sufficient to warrant colonoscopy-based screening. PC-594 therefore represents an opportunity to identify a subset of the general population with high PaC risk.
Publish Date 2015-06-11 10:11
Citation Ritchie SA, Chitou B, Zheng Q, Jayasinghe D, Jin W, Mochizuki A, Goodenowe DB. Pancreatic cancer serum biomarker PC-594: Diagnostic performance and comparison to CA19-9. World J Gastroenterol 2015; 21(21): 6604-6612
URL http://www.wjgnet.com/1007-9327/full/v21/i21/6604.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i21.6604
Full Article (PDF) WJG-21-6604.pdf
Full Article (Word) WJG-21-6604.doc
Manuscript File 16283-Review.docx
Answering Reviewers 16283-Answering reviewers.pdf
Audio Core Tip 16283-Audio core tip.mp3
Biostatistics Review Certificate 16283-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 16283-Conflict-of-interest statement.pdf
Copyright License Agreement 16283-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20150107231858.pdf
Institutional Review Board Approval Form or Document 16283-Institutional review board statement.pdf
Peer-review Report 16283-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16283-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16283-Scientific misconduct check.pdf
Scientific Editor Work List 16283-Scientific editor work list.pdf