BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/11/2015 10:11:00 AM | Browse: 1493 | Download: 2348
 |
Received |
|
2015-01-08 08:32 |
|
Peer-Review Started |
|
2015-01-08 16:32 |
|
To Make the First Decision |
|
2015-01-22 16:40 |
|
Return for Revision |
|
2015-02-02 08:09 |
|
Revised |
|
2015-02-11 05:32 |
|
Second Decision |
|
2015-03-09 14:32 |
|
Accepted by Journal Editor-in-Chief |
|
2015-03-12 21:29 |
|
Accepted by Executive Editor-in-Chief |
|
2015-03-19 16:57 |
|
Articles in Press |
|
2015-03-19 17:44 |
 |
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2015-05-21 17:08 |
|
Publish the Manuscript Online |
|
2015-06-11 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Allergy |
| Manuscript Type |
Case Control Study |
| Article Title |
Pancreatic cancer serum biomarker PC-594: Diagnostic performance and comparison to CA19-9
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shawn A Ritchie, Bassirou Chitou, Qingan Zheng, Dushmanthi Jayasinghe, Wei Jin, Asuka Mochizuki and Dayan B Goodenowe |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dr. Shawn A Ritchie, Department of Biomarker Discovery and Validation, Phenomenome Discoveries, Inc. 204-407 Downey Road, Saskatoon, SK S7N 4L8, Canada. s.ritchie@phenomenome.com |
| Key Words |
Pancreatic cancer; Risk; Screening; Blood; Fatty acid; Biomarker; Metabolite; PC-594 |
| Core Tip |
The incidence of pancreatic cancer (PaC) in the general population is too low to warrant screening by imaging or endoscopic ultrasound. In this paper, we provide further validation that the serum fatty acid metabolite PC-594 is a viable PaC biomarker by showing that it is significantly reduced in North American PaC patients compared to control subjects, and that its performance is superior to CA19-9. This reduction represents a near 10-fold increase for PaC risk, and a PaC incidence among PC-594 deficient subjects that exceeds the incidence of colorectal cancer considered sufficient to warrant colonoscopy-based screening. PC-594 therefore represents an opportunity to identify a subset of the general population with high PaC risk. |
| Publish Date |
2015-06-11 10:11 |
| Citation |
Ritchie SA, Chitou B, Zheng Q, Jayasinghe D, Jin W, Mochizuki A, Goodenowe DB. Pancreatic cancer serum biomarker PC-594: Diagnostic performance and comparison to CA19-9. World J Gastroenterol 2015; 21(21): 6604-6612 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i21/6604.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i21.6604 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
