Publication Name	World Journal of Gastroenterology
Manuscript ID	1630
Country	China

Received	2012-12-24 19:38
Peer-Review Started	2012-12-24 21:34
To Make the First Decision	2013-01-09 15:53
Return for Revision	2013-01-16 16:41
Revised
Second Decision	2013-03-26 17:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-27 12:56
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-04-07 13:32
Typeset the Manuscript	2013-04-08 11:20
Publish the Manuscript Online	2013-04-19 20:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice
Manuscript Source	Invited Manuscript
All Author List	Xue-Cheng Sun, Jing-Yi Yan, Xiao-Lei Chen, Ying-Peng Huang, Xian Shen and Xiao-Hua Ye
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province Y201016273
Corresponding Author	Jing-Yi Yan, Associate Chief Physician, Department of Gastroenterology and General Surgery, the First Affiliated Hospital of Wenzhou Medical College, No 2 Fuxue Road, Wenzhou 325000, Zhejiang Province, China. yjy751231@126.com
Key Words	Gastrointestinal stromal tumor; Phosphorothioate antisense oligonucleotides; Imatinib; Tumor inhibitory rate; Telomerase activity
Core Tip	Gastrointestinal stromal tumors (GISTs) are low-grade malignant mesenchymal tumors of the gastrointestinal tract. In our study, telomerase activity was repressed and the level of B-cell leukemia/lymphoma 2 mRNA markedly downregulated in SCID mice carrying transplanted human GISTs and treated with telomerase RNA-targeting phosphorothioate antisense oligodeoxynucleotides (PS-ASODN). Therefore, the therapeutic effect of PS-ASODN on GISTs is remarkable.
Publish Date	2013-04-19 20:40
Citation	Sun XC, Yan JY, Chen XL, Huang YP, Shen X, Ye XH. Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice. World J Gastroenterol 2013; 19(15): 2340-2347
URL	http://www.wjgnet.com/1007-9327/full/v19/i15/2340.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i15.2340

Full Article (PDF)	WJG-19-2340.pdf
Manuscript File	1630-Review.doc
Answering Reviewers	1630-Answering reviewers.doc
Copyright License Agreement	1630-Copyright assignment.pdf
Peer-review Report	1630-Peer review(s).pdf
Scientific Editor Work List	1630-Scientific editor work list.doc