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12/2/2015 11:50:00 AM | Browse: 993 | Download: 1241
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 16300
Country/Territory Germany
Received
2015-01-09 08:23
Peer-Review Started
2015-01-10 14:12
To Make the First Decision
2015-03-06 10:32
Return for Revision
2015-03-11 11:30
Revised
2015-03-16 19:05
Second Decision
2015-05-25 11:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-06-02 17:22
Articles in Press
2015-06-02 17:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-07-23 12:26
Publish the Manuscript Online
2015-08-17 16:11
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis
Manuscript Source Invited Manuscript
All Author List Linda Hammerich and Frank Tacke
Funding Agency and Grant Number
Funding Agency Grant Number
German Research Foundation DFG Ta434/3-1
German Research Foundation SFB/TRR57
Interdisciplinary Center for Clinical Research (IZKF) Aachen
Corresponding Author Frank Tacke, MD, PhD, Department of Medicine III, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. frank.tacke@gmx.net
Key Words Myeloid derived suppressor cells; Inter­leukin-10; Treg; Liver cirrhosis; Macrophage; Hepatitis C virus
Core Tip Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immune-suppressive cells with important roles during inflammation, infection and cancer. The liver is a primary site for MDSC induction and accumulation, and recent studies linked these cells to the pathogenesis of hepatic inflammation, fibrosis and hepatocellular carcinoma. MDSC can limit tissue injury during acute hepatitis, while they may favor viral persistence in chronic hepatitis. MDSC are also induced during development of liver cancer and suppress anti-tumoral immunity, but their involvement in hepatic fibrosis is less clear. Thus, modulating MDSC functionality might represent a promising novel therapeutic target for liver diseases.
Publish Date 2015-08-17 16:11
Citation Hammerich L, Tacke F. Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis. World J Gastrointest Pathophysiol 2015; 6(3): 43-50
URL http://www.wjgnet.com/2150-5330/full/v6/i3/43.htm
DOI http://dx.doi.org/10.4291/wjgp.v6.i3.43
Full Article (PDF) WJGP-6-43.pdf
Full Article (Word) WJGP-6-43.doc
Manuscript File 16300-Review.docx
Answering Reviewers 16300-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 16300-Conflict-of-interest statement.pdf
Copyright License Agreement 16300-Copyright assignment.pdf
Peer-review Report 16300-Peer-review(s).pdf
Scientific Misconduct Check 16300-Scientific misconduct check.pdf
Scientific Editor Work List 16300-Scientific editor work list.pdf