Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	16300
Country	Germany

Received	2015-01-09 08:23
Peer-Review Started	2015-01-10 14:12
To Make the First Decision	2015-03-06 10:32
Return for Revision	2015-03-11 11:30
Revised	2015-03-16 19:05
Second Decision	2015-05-25 11:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-06-02 17:22
Articles in Press	2015-06-02 17:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-23 12:26
Publish the Manuscript Online	2015-08-17 16:11

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis
Manuscript Source	Invited Manuscript
All Author List	Linda Hammerich and Frank Tacke
Funding Agency and Grant Number	Funding Agency Grant Number German Research Foundation DFG Ta434/3-1 German Research Foundation SFB/TRR57 Interdisciplinary Center for Clinical Research (IZKF) Aachen
Corresponding Author	Frank Tacke, MD, PhD, Department of Medicine III, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. frank.tacke@gmx.net
Key Words	Myeloid derived suppressor cells; Inter­leukin-10; Treg; Liver cirrhosis; Macrophage; Hepatitis C virus
Core Tip	Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immune-suppressive cells with important roles during inflammation, infection and cancer. The liver is a primary site for MDSC induction and accumulation, and recent studies linked these cells to the pathogenesis of hepatic inflammation, fibrosis and hepatocellular carcinoma. MDSC can limit tissue injury during acute hepatitis, while they may favor viral persistence in chronic hepatitis. MDSC are also induced during development of liver cancer and suppress anti-tumoral immunity, but their involvement in hepatic fibrosis is less clear. Thus, modulating MDSC functionality might represent a promising novel therapeutic target for liver diseases.
Publish Date	2015-08-17 16:11
Citation	Hammerich L, Tacke F. Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis. World J Gastrointest Pathophysiol 2015; 6(3): 43-50
URL	http://www.wjgnet.com/2150-5330/full/v6/i3/43.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i3.43

Full Article (PDF)	WJGP-6-43.pdf
Full Article (Word)	WJGP-6-43.doc
Manuscript File	16300-Review.docx
Answering Reviewers	16300-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	16300-Conflict-of-interest statement.pdf
Copyright License Agreement	16300-Copyright assignment.pdf
Peer-review Report	16300-Peer-review(s).pdf
Scientific Misconduct Check	16300-Scientific misconduct check.pdf
Scientific Editor Work List	16300-Scientific editor work list.pdf