Publication Name	World Journal of Gastroenterology
Manuscript ID	16317
Country	Egypt

Received	2015-01-11 13:29
Peer-Review Started	2015-01-11 13:37
To Make the First Decision	2015-02-10 15:52
Return for Revision	2015-02-13 11:18
Revised	2015-02-20 20:14
Second Decision	2015-03-25 17:07
Accepted by Journal Editor-in-Chief	2015-03-26 00:32
Accepted by Executive Editor-in-Chief	2015-03-31 10:12
Articles in Press	2015-03-31 11:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-19 12:40
Publish the Manuscript Online	2015-05-13 10:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Reversibility and heritability of liver fibrosis: Implications for research and therapy
Manuscript Source	Invited Manuscript
All Author List	Hussein M Atta
Funding Agency and Grant Number	Funding Agency Grant Number Egyptian Science and Technology Development Fund under Project 1550
Corresponding Author	Hussein M Atta, MD, PhD, Professor, Department of Surgery, Faculty of Medicine, Minia University, Misr-Aswan Road, El-Minia 61519, Egypt. atta@mu.edu.eg
Key Words	Epigenetics; Epimutations; Inheritance; Liver cirrhosis; Hepatic stellate cells; Histone modification; DNA methylation; MicroRNA; Long noncoding RNA; Transcription regulation
Core Tip	Liver fibrosis, if untreated, progresses to cirrhosis and liver failure or malignancy. Liver fibrosis is reversible and potentially heritable process. Heritability and complete reversibility of liver fibrosis although debatable are of profound importance for research and therapy. Epigenetic mechanisms regulate both processes and hold the key for deciphering their regulatory mechanisms and providing new and much needed therapeutic options.
Publish Date	2015-05-13 10:38
Citation	Atta HM. Reversibility and heritability of liver fibrosis: Implications for research and therapy. World J Gastroenterol 2015; 21(17): 5138-5148
URL	http://www.wjgnet.com/1007-9327/full/v21/i17/5138.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i17.5138

Full Article (PDF)	WJG-21-5138.pdf
Full Article (Word)	WJG-21-5138.doc
Manuscript File	16317-Review.docx
Answering Reviewers	16317-Answering reviewers.pdf
Audio Core Tip	16317-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16317-Conflict-of-interest statement.pdf
Copyright License Agreement	16317-Copyright assignment.pdf
Peer-review Report	16317-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16317-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16317-Scientific misconduct check.pdf
Scientific Editor Work List	16317-Scientific editor work list.pdf