Publication Name	World Journal of Gastroenterology
Manuscript ID	16353
Country	Italy

Received	2015-01-13 08:31
Peer-Review Started	2015-01-13 20:22
To Make the First Decision	2015-03-10 20:28
Return for Revision	2015-03-13 10:37
Revised	2015-03-26 05:42
Second Decision	2015-04-21 12:16
Accepted by Journal Editor-in-Chief	2015-04-23 22:08
Accepted by Executive Editor-in-Chief	2015-05-04 18:17
Articles in Press	2015-05-04 18:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-24 19:26
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Controversy in the diagnosis of pediatric non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Pierluigi Marzuillo, Anna Grandone, Laura Perrone and Emanuele Miraglia del Giudice
Funding Agency and Grant Number
Corresponding Author	Emanuele Miraglia del Giudice, Professor, Department of women and children and general and specialized surgery, Seconda Università degli Studi di Napoli, Via L. De Crecchio 2, 80138 Naples, Italy. emanuele.miraglia@unina2.it
Key Words	Pediatric; Non-alcoholic fatty liver disease; Biopsy; Liver; Ultrasound; Alanine transaminase
Core Tip	Because of the rising obesity prevalence, the non-alcoholic fatty liver disease (NAFLD) has become the most common form of liver disease in childhood. The diagnostic gold standard is represented by hepatic biopsy but the use of liver biopsy in clinical practice causes debate among health care providers because most patients with NAFLD have a good prognosis and, therefore, the risks of a liver biopsy seem to outweigh the clinical benefits. The liver biopsy limitations have led the clinicians to use non-invasive methods to diagnose and stage NAFLD. In this editorial the main diagnostic controversies in pediatric NAFLD are examined.
Publish Date	2015-06-11 10:11
Citation	Marzuillo P, Grandone A, Perrone L, Miraglia del Giudice E. Controversy in the diagnosis of pediatric non-alcoholic fatty liver disease. World J Gastroenterol 2015; 21(21): 6444-6450
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6444.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6444

Full Article (PDF)	WJG-21-6444.pdf
Full Article (Word)	WJG-21-6444.doc
Manuscript File	16353-Review.doc
Answering Reviewers	16353-Answering reviewers.pdf
Audio Core Tip	16353-Audio core tip.mp3
Copyright License Agreement	16353-Copyright assignment.pdf
Peer-review Report	16353-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16353-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16353-Scientific misconduct check.pdf
Scientific Editor Work List	16353-Scientific editor work list.pdf