Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	16354
Country	Greece

Received	2015-01-13 08:30
Peer-Review Started	2015-01-15 22:38
To Make the First Decision	2015-03-06 10:19
Return for Revision	2015-03-11 08:30
Revised	2015-03-24 03:14
Second Decision	2015-04-10 18:19
Accepted by Journal Editor-in-Chief	2015-04-10 20:13
Accepted by Executive Editor-in-Chief	2015-04-20 14:43
Articles in Press	2015-04-20 14:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-24 10:33
Publish the Manuscript Online	2015-04-29 16:58

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Clinical relevance of clopidogrel-proton pump inhibitors interaction
Manuscript Source	Invited Manuscript
All Author List	Stella D Bouziana and Konstantinos Tziomalos
Funding Agency and Grant Number
Corresponding Author	Konstantinos Tziomalos, MD, PhD, Assistant Professor of Internal Medicine, First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Kiriakidi 1, 54636 Thessaloniki, Greece. ktziomalos@yahoo.com
Key Words	Clopidogrel; Esomeprazole; Lansoprazole; Pantoprazole; Rabeprazole; Omeprazole; Cardiovascular risk; Proton pump inhibitors
Core Tip	Even though pharmacodynamic studies suggest that omeprazole can attenuate the antiplatelet effect of clopidogrel, this interaction does not appear to translate into increased cardiovascular risk in patients treated with this combination in observational studies. In the only randomized, double-blind, placebo-controlled study that assessed the cardiovascular implications of combining clopidogrel and omeprazole, patients treated with clopidogrel/omeprazole combination had reduced risk for gastrointestinal events and similar risk for cardiovascular events. Other proton pump inhibitors also do not appear to interact with clopidogrel. However, given the limitations of existing studies, the decision to administer proton pump inhibitors to patients treated with clopidogrel should be individualized based on the patient’s bleeding and cardiovascular risk.
Publish Date	2015-04-29 16:58
Citation	Bouziana SD, Tziomalos K. Clinical relevance of clopidogrel-proton pump inhibitors interaction. World J Gastrointest Phar¬macol Ther 2015; 6(2): 17-21
URL	http://www.wjgnet.com/2150-5349/full/v6/i2/17.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v6.i2.17

Full Article (PDF)	WJGPT-6-17.pdf
Full Article (Word)	WJGPT-6-17.doc
Manuscript File	16354-Review.doc
Answering Reviewers	16354-Answering reviewers.pdf
Audio Core Tip	16354-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16354-Conflict-of-interest statement.pdf
Copyright License Agreement	16354-Copyright assignment.pdf
Peer-review Report	16354-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16354-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16354-Scientific misconduct check.pdf
Scientific Editor Work List	16354-Scientific editor work list.pdf