Publication Name	World Journal of Gastroenterology
Manuscript ID	16371
Country	Italy

Received	2015-01-14 08:28
Peer-Review Started	2015-01-14 14:38
To Make the First Decision	2015-03-26 18:20
Return for Revision	2015-03-27 10:38
Revised	2015-04-10 14:12
Second Decision	2015-05-13 07:32
Accepted by Journal Editor-in-Chief	2015-05-13 23:20
Accepted by Executive Editor-in-Chief	2015-05-21 17:22
Articles in Press	2015-05-21 17:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-15 15:19
Publish the Manuscript Online	2015-06-29 16:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatitis C treatment in the elderly: New possibilities and controversies towards interferon-free regimens
Manuscript Source	Invited Manuscript
All Author List	Umberto Vespasiani-Gentilucci, Giovanni Galati, Paolo Gallo, Antonio De Vincentis, Elisabetta Riva and Antonio Picardi
Funding Agency and Grant Number
Corresponding Author	Umberto Vespasiani-Gentilucci, MD, PhD, Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, Italy. u.vespasiani@unicampus.it
Key Words	Hepatitis C virus; Elderly; Interferon; Ribavirin; Telaprevir; Boceprevir; Sofosbuvir; Simeprevir; Daclatasvir; Side effects; Drug-drug interactions
Core Tip	Hepatitis C virus (HCV) infection is a significant threat to the health of elderly patients, in whom liver disease progresses very rapidly and extrahepatic complications affect the quality of life. Till now, treatment attempts have been substantially limited by the side effects of interferon (IFN). Here we discuss how the availability of IFN-free regimens should prompt us to change our mind when assessing treatment indication and to consider a significantly larger number of possible candidates among elderly patients. Drug-drug interactions and assessment of liver disease-dependent vs comorbidities-dependent life expectancy, rather than anagraphic age, are likely to guide the choice of the aged HCV patients to be treated in the next future.
Publish Date	2015-06-29 16:33
Citation	Vespasiani-Gentilucci U, Galati G, Gallo P, De Vincentis A, Riva E, Picardi A. Hepatitis C treatment in the elderly: New possibilities and controversies towards interferon-free regimens. World J Gastroenterol 2015; 21(24): 7412-7426
URL	http://www.wjgnet.com/1007-9327/full/v21/i24/7412.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i24.7412

Full Article (PDF)	WJG-21-7412.pdf
Full Article (Word)	WJG-21-7412.doc
Manuscript File	16371-Review.docx
Answering Reviewers	16371-Answering reviewers.pdf
Audio Core Tip	16371-Audio core tip.wav
Conflict-of-Interest Disclosure Form	16371-Conflict-of-interest statement.pdf
Copyright License Agreement	16371-Copyright assignment.pdf
Peer-review Report	16371-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16371-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16371-Scientific misconduct check.pdf
Scientific Editor Work List	16371-Scientific editor work list.pdf