Publication Name	World Journal of Hepatology
Manuscript ID	16373
Country	Mexico

Received	2015-01-14 08:21
Peer-Review Started	2015-01-18 13:03
To Make the First Decision	2015-02-07 14:54
Return for Revision	2015-02-10 14:35
Revised	2015-02-21 03:59
Second Decision	2015-03-09 09:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-03-18 17:20
Articles in Press	2015-03-18 17:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-04-01 23:20
Typeset the Manuscript	2015-05-14 14:48
Publish the Manuscript Online	2015-06-03 12:00

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Fátima Higuera-de la Tijera and Alfredo I Servín-Caamaño
Funding Agency and Grant Number
Corresponding Author	Fátima Higuera-de la Tijera, MD, MSc, Liver Clinic, Gastroenterology Department, Mexico’s General Hospital “Dr. Eduardo Liceaga”, Eje 2A Sur (Dr. Balmis) 148, Cuauhtémoc, Doctores, Mexico City 06726, Mexico. fatimahiguera@yahoo.com.mx
Key Words	Insulin resistance; Lipotoxicity; Non-alcoholic steatohepatitis; Physiopathology; Therapeutic targets
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is an important health care problem. The pathophysiology of NAFLD and non-alcoholic steatohepatitis (NASH) and their progression are multifactorial and complex processes, where multi-parallel simultaneous hits derived from the gut and adipose tissue promote a pro-inflammatory response and liver injury. All of these represent attractive therapeutic targets. Pharmacological agents such as glucagon-like peptide-1 agonists, dipeptidyl peptidase-4 inhibitors, ursodeoxycholic acid, obeticholic acid and probiotics need to be explored in clinical trials specifically for treating NAFLD and NASH.
Publish Date	2015-06-03 12:00
Citation	Higuera-de la Tijera F, Servín-Caamaño AI. Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets. World J Hepatol 2015; 7(10): 1297-1301
URL	http://www.wjgnet.com/1948-5182/full/v7/i10/1297.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i10.1297

Full Article (PDF)	WJH-7-1297.pdf
Full Article (Word)	WJH-7-1297.doc
Manuscript File	16373-Review.docx
Answering Reviewers	16373-Answering reviewers.pdf
Audio Core Tip	16373-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16373-Conflict-of-interest statement.pdf
Copyright License Agreement	16373-Copyright assignment.pdf
Peer-review Report	16373-Peer-review(s).pdf
Scientific Misconduct Check	16373-Scientific misconduct check.pdf
Scientific Editor Work List	16373-Scientific editor work list.pdf