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Articles Published Processes
9/28/2015 11:46:00 AM | Browse: 1113 | Download: 2252
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Received |
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2015-01-15 08:49 |
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Peer-Review Started |
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2015-01-16 10:32 |
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To Make the First Decision |
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2015-04-24 19:18 |
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Return for Revision |
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2015-04-27 19:26 |
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Revised |
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2015-05-23 17:16 |
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Second Decision |
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2015-07-27 20:04 |
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Accepted by Journal Editor-in-Chief |
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2015-07-27 21:31 |
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Accepted by Executive Editor-in-Chief |
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2015-08-31 13:17 |
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Articles in Press |
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2015-08-31 13:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-09-07 11:31 |
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Typeset the Manuscript |
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2015-09-11 11:20 |
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Publish the Manuscript Online |
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2015-09-28 11:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Ursodeoxycholic acid induces apoptosis in hepatocellular carcinoma xenografts in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui Liu, Hong-Wei Xu, Yu-Zhen Zhang, Ya Huang, Guo-Qing Han, Tie-Jun Liang, Li-Li Wei, Cheng-Yong Qin and Cheng-Kun Qin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Provincial Science and Technology Committee of China |
2013GSF11852 |
| Shandong Provincial Natural Science Foundation of China |
ZR2014HM106 |
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| Corresponding Author |
Dr. Cheng-Kun Qin, Department of General Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Weiqi Road, Jinan 250021, Shandong Province, China. qin_chengkun@163.com
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| Key Words |
Hepatocellular carcinoma; Inhibitory effects; Mechanisms; Ursodeoxycholic acid; Xenografts |
| Core Tip |
Hepatocellular carcinoma (HCC) ranks as the sixth most common cancer worldwide. Prognosis of HCC patients remains poor, however, due to the lack of effective therapies. In this study, ursodeoxycholic acid (UDCA) was investigated as a potential chemotherapeutic agent in a mouse model of HCC. Tumor growth was inhibited by increasing concentrations of UDCA over a 21-d period, and the effect was elicited through apoptosis. UDCA is thus a candidate chemopreventive and chemotherapeutic agent for HCC.
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| Publish Date |
2015-09-28 11:42 |
| Citation |
Liu H, Xu HW, Zhang YZ, Huang Y, Han GQ, Liang TJ, Wei LL, Qin CY, Qin CK. Ursodeoxycholic acid induces apoptosis in hepatocellular carcinoma xenografts in mice. World J Gastroenterol 2015; 21(36): 10367-10374 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i36/10367.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i36.10367 |
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