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7/14/2015 12:17:00 PM | Browse: 524 | Download: 1019
Publication Name World Journal of Gastroenterology
Manuscript ID 16393
Country/Territory Spain
Received
2015-01-15 08:46
Peer-Review Started
2015-01-16 10:48
To Make the First Decision
2015-02-10 15:56
Return for Revision
2015-02-13 12:13
Revised
2015-02-25 01:00
Second Decision
2015-03-29 10:05
Accepted by Journal Editor-in-Chief
2015-03-29 15:37
Accepted by Company Editor-in-Chief
2015-04-03 13:47
Articles in Press
2015-04-03 13:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-16 18:43
Publish the Manuscript Online
2015-07-14 12:17
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation
Manuscript Source Invited Manuscript
All Author List Eirini Pantazi, Mohamed Bejaoui, Mohamed Amine Zaouali, Emma Folch-Puy, Anabela Pinto Rolo, Arnau Panisello, Carlos Marques Palmeira and Joan Roselló-Catafau
Funding Agency and Grant Number
Funding Agency Grant Number
Fondo de Investigaciones Sanitarias FIS PI12/00519
Agència de Gestió d’Ajuts Universitaris i de Recerca 2012FI_B00382
Generalitat de Catalunya, Barcelona, Catalonia, Spain to Pantazi E
Corresponding author Joan Roselló-Catafau, Professor, Experimental Pathology Department, Experimental Hepatic Ischemia-Reperfusion Unit, Institute of Biomedical Research of Barcelona (IIBB-CSIC), C/Rosello 161, 7th floor, 08036 Barcelona, Spain. jrcbam@iibb.csic.es
Key Words Losartan; Sirtuin 1; Endoplasmic reticulum stress; Liver ischemia reperfusion injury; Angiotensin Ⅱ
Core Tip Losartan is an angiotensin Ⅱ type 1 receptor (AT1R) antagonist known to protect livers against ischemia-reperfusion injury (IRI). However, the mechanisms underlying this hepatoprotective effect are not fully understood, especially in case of reduced-size orthotopic liver transplantation (ROLT). SIRT1 has recently emerged as an important target to modulate for alleviating IRI. In our study, we describe that AT1R antagonism enhances SIRT1 activity and prevents endoplasmic reticulum stress and liver apoptosis in a rat model of ROLT. Consequently, losartan increases the resistance of ROLT grafts against IRI.
Publish Date 2015-07-14 12:17
Citation Pantazi E, Bejaoui M, Zaouali MA, Folch-Puy E, Pinto Rolo A, Panisello A, Palmeira CM, Roselló-Catafau J. Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation. World J Gastroenterol 2015; 21(26): 8021-8031
Url http://www.wjgnet.com/1007-9327/full/v21/i26/8021.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i26.8021
Full Article (PDF) WJG-21-8021.pdf
Full Article (Word) WJG-21-8021.doc
Manuscript File 16393-Review.docx
Answering Reviewers 16393-Answering reviewers.pdf
Audio Core Tip 16393-Audio core tip.mp3
Biostatistics Review Certificate 16393-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 16393-Conflict-of-interest statement.pdf
Copyright License Agreement 16393-Copyright assignment.pdf
Data Sharing Statement 16393-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 16393-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 16393-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 16393-Language certificate.pdf
Peer-review Report 16393-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16393-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16393-Scientific misconduct check.pdf
Scientific Editor Work List 16393-Scientific editor work list.pdf