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Articles Published Processes
7/14/2015 12:17:00 PM | Browse: 1157 | Download: 2269
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Received |
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2015-01-15 08:46 |
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Peer-Review Started |
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2015-01-16 10:48 |
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To Make the First Decision |
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2015-02-10 15:56 |
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Return for Revision |
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2015-02-13 12:13 |
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Revised |
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2015-02-25 01:00 |
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Second Decision |
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2015-03-29 10:05 |
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Accepted by Journal Editor-in-Chief |
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2015-03-29 15:37 |
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Accepted by Executive Editor-in-Chief |
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2015-04-03 13:47 |
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Articles in Press |
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2015-04-03 13:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-06-16 18:43 |
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Publish the Manuscript Online |
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2015-07-14 12:17 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eirini Pantazi, Mohamed Bejaoui, Mohamed Amine Zaouali, Emma Folch-Puy, Anabela Pinto Rolo, Arnau Panisello, Carlos Marques Palmeira and Joan Roselló-Catafau |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondo de Investigaciones Sanitarias |
FIS PI12/00519 |
| Agència de Gestió d’Ajuts Universitaris i de Recerca |
2012FI_B00382 |
| Generalitat de Catalunya, Barcelona, Catalonia, Spain |
to Pantazi E |
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| Corresponding Author |
Joan Roselló-Catafau, Professor, Experimental Pathology Department, Experimental Hepatic Ischemia-Reperfusion Unit, Institute of Biomedical Research of Barcelona (IIBB-CSIC), C/Rosello 161, 7th floor, 08036 Barcelona, Spain. jrcbam@iibb.csic.es |
| Key Words |
Losartan; Sirtuin 1; Endoplasmic reticulum stress; Liver ischemia reperfusion injury; Angiotensin Ⅱ |
| Core Tip |
Losartan is an angiotensin Ⅱ type 1 receptor (AT1R) antagonist known to protect livers against ischemia-reperfusion injury (IRI). However, the mechanisms underlying this hepatoprotective effect are not fully understood, especially in case of reduced-size orthotopic liver transplantation (ROLT). SIRT1 has recently emerged as an important target to modulate for alleviating IRI. In our study, we describe that AT1R antagonism enhances SIRT1 activity and prevents endoplasmic reticulum stress and liver apoptosis in a rat model of ROLT. Consequently, losartan increases the resistance of ROLT grafts against IRI. |
| Publish Date |
2015-07-14 12:17 |
| Citation |
Pantazi E, Bejaoui M, Zaouali MA, Folch-Puy E, Pinto Rolo A, Panisello A, Palmeira CM, Roselló-Catafau J. Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation. World J Gastroenterol 2015; 21(26): 8021-8031 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i26/8021.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i26.8021 |
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