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Articles Published Processes
6/29/2015 4:40:00 PM | Browse: 944 | Download: 1525
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Received |
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2015-01-15 08:37 |
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Peer-Review Started |
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2015-01-15 08:46 |
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To Make the First Decision |
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2015-03-10 20:36 |
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Return for Revision |
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2015-03-12 10:29 |
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Revised |
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2015-03-25 02:22 |
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Second Decision |
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2015-05-11 08:42 |
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Accepted by Journal Editor-in-Chief |
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2015-05-11 20:41 |
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Accepted by Executive Editor-in-Chief |
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2015-05-21 17:25 |
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Articles in Press |
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2015-05-21 17:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-06-14 19:17 |
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Publish the Manuscript Online |
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2015-06-29 16:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jason Lamontagne, Laura F Steel and Michael J Bouchard |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Pennsylvania state CURE grant |
4100057658(to Steel LF and Bouchard MJ, partially) |
| Ruth L Kirschstein (F31) Predoctoral Fellowship |
5F31CA171712-03(to Lamontagne J, partially) |
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| Corresponding Author |
Michael J Bouchard, PhD, Department of Biochemistry, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, United States. michael.bouchard@drexelmed.edu |
| Key Words |
Hepatitis B virus; MicroRNA; Hepatocellular carcinoma; Hepatitis B virus replication |
| Core Tip |
In this review, we discuss the current state of our understanding of how hepatitis B virus (HBV) affects the expression profile of cellular microRNAs (miRNAs), how these miRNAs impact HBV replication, and the relationship between HBV-mediated miRNA regulation and hepatocellular carcinoma development. Importantly, we address challenges in studying the relationship between HBV and miRNAs, including the lack of an experimental system that effectively models HBV infection and a reliance on the use of transformed cell lines. Finally, we propose applications of techniques to address the functional impact of HBV-mediated regulation of miRNA expression, which could enhance our understanding of the role miRNAs play in HBV replication and disease. |
| Publish Date |
2015-06-29 16:33 |
| Citation |
Lamontagne J, Steel LF, Bouchard MJ. Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases. World J Gastroenterol 2015; 21(24): 7375-7399 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i24/7375.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i24.7375 |
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