Publication Name	World Journal of Hepatology
Manuscript ID	16396
Country	Italy

Received	2015-01-15 08:34
Peer-Review Started	2015-01-16 10:58
To Make the First Decision	2015-03-06 10:19
Return for Revision	2015-03-11 08:44
Revised	2015-03-20 00:54
Second Decision	2015-04-10 18:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-20 14:44
Articles in Press	2015-04-20 14:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-25 18:12
Publish the Manuscript Online	2015-06-16 14:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Understanding the pathophysiological mechanisms in the pediatric non-alcoholic fatty liver disease: The role of genetics
Manuscript Source	Invited Manuscript
All Author List	Pierluigi Marzuillo, Anna Grandone, Laura Perrone and Emanuele Miraglia del Giudice
Funding Agency and Grant Number
Corresponding Author	Pierluigi Marzuillo, MD, Department of Women and Children and General and Specialized Surgery, Seconda Università degli Studi di Napoli, Via L. De Crecchio 2, 80138 Naples, Italy. pierluigi.marzuillo@gmail.com
Key Words	Pediatric non-alcoholic fatty liver disease; GPR120; PNPLA3; TM6SF2; Alanine transaminase
Core Tip	At the present time, the two hits hypothesis needs to be updated because of the discovery of new genetic polymorphisms involved both in the liver fat accumulation and progression to nonalcoholic steatohepatitis that make more intriguing understanding the non-alcoholic fatty liver disease (NAFLD) patho-physiological mechanisms. In this editorial, that is not to consider as a comprehensive review, we want to underline the role of three polymorphisms, one older (PNPLA3 I148M) but very important and two recently discovered (GPR120 R270H and TM6SF2 E167K) that add new pieces to the comprehension of the NAFLD pathophysiological puzzle.
Publish Date	2015-06-16 14:22
Citation	Marzuillo P, Grandone A, Perrone L, Miraglia del Giudice E. Understanding the pathophysiological mechanisms in the pediatric non-alcoholic fatty liver disease: The role of genetics. World J Hepatol 2015; 7(11): 1439-1443
URL	http://www.wjgnet.com/1948-5182/full/v7/i11/1439.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i11.1439

Full Article (PDF)	WJH-7-1439.pdf
Full Article (Word)	WJH-7-1439.doc
Manuscript File	16396-Review.doc
Answering Reviewers	16396-Answering reviewers.pdf
Audio Core Tip	16396-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16396-Conflict-of-interest statement.pdf
Copyright License Agreement	16396-Copyright assignment.pdf
Peer-review Report	16396-Peer-review(s).pdf
Scientific Misconduct Check	16396-Scientific misconduct check.pdf
Scientific Editor Work List	16396-Scientific editor work list.pdf