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Articles Published Processes
1/23/2016 5:08:00 PM | Browse: 982 | Download: 2028
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Received |
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2015-01-15 17:47 |
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Peer-Review Started |
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2015-01-16 14:48 |
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To Make the First Decision |
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2015-03-26 18:23 |
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Return for Revision |
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2015-03-27 15:06 |
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Revised |
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2015-08-04 08:51 |
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Second Decision |
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2015-08-21 13:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-09-02 15:18 |
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Articles in Press |
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2015-09-02 15:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-12-18 09:57 |
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Typeset the Manuscript |
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2016-01-15 14:48 |
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Publish the Manuscript Online |
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2016-01-23 17:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ning Ding, Li Che, Xiao-Lei Li, Yan Liu, Li-Jie Jiang, Biao Fan, Jun-Yan Tao, Xin Chen and Jia-Fu Ji |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
R01CA136606 (in part, to Chen X) |
| UCSF Liver Center |
P30DK026743 |
| China Scholarship Council |
201206010086 (to Ding N) |
| China Scholarship Council |
201306590021 (to Li XL) |
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| Corresponding Author |
Jia-Fu Ji, MD, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. jiafuj@gmail.com |
| Key Words |
IDH1 mutant; Notch pathway; Intrahepatic cholangiocarcinoma; Mouse liver cancer; p53 |
| Core Tip |
We established a novel murine intrahepatic cholangiocarcinoma (ICC) model via hydrodynamic transfection of activated form of Notch1 (NICD), shP53 and IDH1R132C into the mouse liver. This study is the first to demonstrate that IDH1R132C mutant can cooperate with other oncogenes or tumor suppressor genes to promote ICC development in vivo. In addition, it provides the ICC research community with an innovative and convenient approach to generate IDH1R132C mutant ICC in mice. Finally, ICC induced by NICD/shP53/IDH1R132C provides a useful tool to study IDH mutant in ICC pathogenesis and a novel preclinical murine model for testing drugs against the deadly malignancy. |
| Publish Date |
2016-01-23 17:08 |
| Citation |
Ding N, Che L, Li XL, Liu Y, Jiang LJ, Fan B, Tao JY, Chen X, Ji JF. Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice. World J Gastroenterol 2016; 22(6): 2071-2080 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i6/2071.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i6.2071 |
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