Publication Name	World Journal of Gastroenterology
Manuscript ID	16428
Country	Japan

Received	2015-01-17 12:31
Peer-Review Started	2015-01-17 14:29
To Make the First Decision	2015-04-13 16:24
Return for Revision	2015-04-14 17:22
Revised	2015-04-27 18:45
Second Decision	2015-06-12 07:46
Accepted by Journal Editor-in-Chief	2015-06-15 15:44
Accepted by Executive Editor-in-Chief	2015-06-26 15:00
Articles in Press	2015-06-26 15:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-25 15:23
Publish the Manuscript Online	2015-08-08 15:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Reversed portal flow: Clinical influence on the long-term outcomes in cirrhosis
Manuscript Source	Unsolicited Manuscript
All Author List	Takayuki Kondo, Hitoshi Maruyama, Tadashi Sekimoto, Taro Shimada, Masanori Takahashi and Osamu Yokosuka
Funding Agency and Grant Number
Corresponding Author	Hitoshi Maruyama, MD, PhD, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuou-ku, Chiba 260-8670, Japan. maru-cib@umin.ac.jp
Key Words	Non-forward portal flow; Reversed portal flow; Cirrhosis; Doppler ultrasound; Portal hemodynamics
Core Tip	The influence of non-forward portal flow (NFPF) in cirrhosis has not been determined. The present study examined the effect of NFPF on the natural history of cirrhosis in 222 patients (median follow-up period 40.9 mo). The cumulative incidences of NFPF was as follows: 6.5% at 1 year, 14.5% at 3 years, and 23.1% at 5 years. The cumulative survival rate was significantly lower in patients with NFPF (72.2% at 1 year, 38.5% at 3 years, and 38.5% at 5 years) than in those with forward portal flow (84.0% at 1 year, 67.8% at 3 years, and 54.3% at 5 years, P = 0.0123) using Child-Pugh B and C classifications, suggesting the need for careful management of these patients.
Publish Date	2015-08-08 15:26
Citation	Kondo T, Maruyama H, Sekimoto T, Shimada T, Takahashi M, Yokosuka O. Reversed portal flow: Clinical influence on the long-term outcomes in cirrhosis. World J Gastroenterol 2015; 21(29): 8894-8902
URL	http://www.wjgnet.com/1007-9327/full/v21/i29/8894.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i29.8894

Full Article (PDF)	WJG-21-8894.pdf
Full Article (Word)	WJG-21-8894.doc
Manuscript File	16428-Review.doc
Answering Reviewers	16428-Answering reviewers.pdf
Audio Core Tip	16428-Audio core tip.mp3
Biostatistics Review Certificate	16428-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16428-Conflict-of-interest statement.pdf
Copyright License Agreement	16428-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150116182615.pdf
Institutional Review Board Approval Form or Document	16428-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	16428-Language certificate.pdf
Peer-review Report	16428-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16428-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16428-Scientific misconduct check.pdf
Scientific Editor Work List	16428-Scientific editor work list.pdf