Publication Name	World Journal of Gastroenterology
Manuscript ID	16486
Country	China

Received	2015-01-20 09:33
Peer-Review Started	2015-01-20 23:07
To Make the First Decision	2015-02-26 09:22
Return for Revision	2015-02-26 13:47
Revised	2015-03-02 16:09
Second Decision	2015-05-11 08:43
Accepted by Journal Editor-in-Chief	2015-05-11 20:39
Accepted by Executive Editor-in-Chief	2015-05-21 17:39
Articles in Press	2015-05-21 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-06-04 11:40
Typeset the Manuscript	2015-07-06 12:14
Publish the Manuscript Online	2015-07-22 13:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Mechanisms of givinostat inhibiting hepatic stellate cells proliferation and activation of lysine-acetylated proteins
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Gang Wang, Ling Xu, Ting Wang, Jue Wei, Wen-Ying Meng, Na Wang and Min Shi
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Municipal Health Bureau Key Disciplines Grant ZK2012A05 Bootstrap Class Project Foundation of the Science and Technology Commission of Shanghai Municipality 14411973700 Shanghai Municipal Health Bureau 20134100
Corresponding Author	Min Shi, MD, PhD, Professor, Department of Gastroenterology, Shanghai Tongren Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Street, Shanghai 200336, China. shimingdyx@ yeah.net
Key Words	Givinostat; Histone deacetylase inhibitor; Hepatic stellate cells; Nuclear factor kappa B; Superoxide dismutase
Core Tip	At present, there is not an effective therapeutic means for liver fibrosis. Inhibition of hepatic stellate cells (HSCs) activation and proliferation or inducing apoptosis is the mainstream strategy for the treatment of liver fibrosis. As demonstrated in our current study, an histone deacetylase inhibitor, givinostat has antifibrotic activities both in vivo and in vitro, which might be achieved by regulating the acetylation of nuclear factor kappa B and superoxide dismutase, stimulating oxidative stress, activating mitochondrial pathways, inhibiting proliferation of mouse HSCs, and inducing apoptosis. Our current study may provide new directions and evidence in the research and development of new drugs for liver fibrosis.
Publish Date	2015-07-22 13:58
Citation	Wang YG, Xu L, Wang T, Wei J, Meng WY, Wang N, Shi M. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol 2015; 21(27): 8326-8339
URL	http://www.wjgnet.com/1007-9327/full/v21/i27/8326.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i27.8326

Full Article (PDF)	WJG-21-8326.pdf
Full Article (Word)	WJG-21-8326.doc
Manuscript File	16486-Review.doc
Answering Reviewers	16486-Answering reviewers.pdf
Audio Core Tip	16486-Audio core tip .mp3
Biostatistics Review Certificate	16486-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16486-Conflict-of-interest statement.pdf
Copyright License Agreement	16486-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	16486-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	16486-Language certificate.pdf
Peer-review Report	16486-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16486-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16486-Scientific misconduct check.pdf
Scientific Editor Work List	16486-Scientific editor work list.pdf