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Articles Published Processes
11/23/2015 11:10:00 AM | Browse: 1280 | Download: 1651
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Received |
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2015-01-20 18:01 |
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Peer-Review Started |
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2015-01-20 21:06 |
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To Make the First Decision |
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2015-04-10 17:17 |
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Return for Revision |
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2015-04-20 13:44 |
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Revised |
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2015-05-02 09:31 |
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Second Decision |
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2015-08-27 11:24 |
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Accepted by Journal Editor-in-Chief |
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2015-08-27 21:41 |
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Accepted by Executive Editor-in-Chief |
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2015-09-02 10:45 |
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Articles in Press |
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2015-09-02 10:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-11-03 07:23 |
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Publish the Manuscript Online |
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2015-11-23 10:19 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Signal transducer and activator of transcription 3 regulation by novel binding partners
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tadashi Matsuda, Ryuta Muromoto, Yuichi Sekine, Sumihito Togi, Yuichi Kitai, Shigeyuki Kon and Kenji Oritani |
| Funding Agency and Grant Number |
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| Corresponding Author |
Tadashi Matsuda, PhD, Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-Ku Kita 12 Nishi 6, Sapporo 060-0812, Japan. tmatsuda@pharm.hokudai.ac.jp |
| Key Words |
Janus kinase/signal transducer and activator of transcription; Signal transduction; Signal transducer and activator of transcription 3; DAXX; Zipper-interacting protein kinase; Krüppel-associated box-associated protein 1; Y14; PDZ and LIM domain 2; Signal transducing adaptor protein-2; Nuclear factor-κB |
| Core Tip |
Signal transducer and activator of transcription 3 (STAT3) has been proposed its physiological and pathological significance in malignant and inflammatory diseases; therefore, the targeting of the STAT3 pathways is likely to be suitable for clinical application. In this review, we introduced novel regulatory molecules of STAT3 binding partners, such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2. These proteins positively or negatively regulate critical steps of STAT3-mediated signals via individually unique mechanism. We hope that the infor?mation described here will help to develop a new strategy to clinically control the STAT3 activities. |
| Publish Date |
2015-11-23 10:19 |
| Citation |
Matsuda T, Muromoto R, Sekine Y, Togi S, Kitai Y, Kon S, Oritani K.. Signal transducer and activator of transcription 3 regulation by novel binding partners. World J Biol Chem 2015; 6(4): 324-332 |
| URL |
http://www.wjgnet.com/1949-8454/full/v6/i4/324.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v6.i4.324 |
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