Publication Name	World Journal of Biological Chemistry
Manuscript ID	16502
Country	Japan

Received	2015-01-20 18:01
Peer-Review Started	2015-01-20 21:06
First Decision by Editorial Office Director
Return for Revision	2015-04-20 13:44
Revised	2015-05-02 09:31
Publication Fee Transferred
Second Decision by Editor	2015-08-27 11:24
Second Decision by Editor-in-Chief	2015-08-27 21:41
Final Decision by Editorial Office Director	2015-09-02 10:45
Articles in Press	2015-09-02 10:45
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:23
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Signal transducer and activator of transcription 3 regulation by novel binding partners
Manuscript Source	Invited Manuscript
All Author List	Tadashi Matsuda, Ryuta Muromoto, Yuichi Sekine, Sumihito Togi, Yuichi Kitai, Shigeyuki Kon and Kenji Oritani
Funding Agency and Grant Number
Corresponding Author	Tadashi Matsuda, PhD, Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-Ku Kita 12 Nishi 6, Sapporo 060-0812, Japan. tmatsuda@pharm.hokudai.ac.jp
Key Words	Janus kinase/signal transducer and activator of transcription; Signal transduction; Signal transducer and activator of transcription 3; DAXX; Zipper-interacting protein kinase; Krüppel-associated box-associated protein 1; Y14; PDZ and LIM domain 2; Signal transducing adaptor protein-2; Nuclear factor-κB
Core Tip	Signal transducer and activator of transcription 3 (STAT3) has been proposed its physiological and pathological significance in malignant and inflammatory diseases; therefore, the targeting of the STAT3 pathways is likely to be suitable for clinical application. In this review, we introduced novel regulatory molecules of STAT3 binding partners, such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2. These proteins positively or negatively regulate critical steps of STAT3-mediated signals via individually unique mechanism. We hope that the infor?mation described here will help to develop a new strategy to clinically control the STAT3 activities.
Publish Date	2015-11-23 10:19
Citation	Matsuda T, Muromoto R, Sekine Y, Togi S, Kitai Y, Kon S, Oritani K.. Signal transducer and activator of transcription 3 regulation by novel binding partners. World J Biol Chem 2015; 6(4): 324-332
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/324.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.324

Full Article (PDF)	WJBC-6-324.pdf
Full Article (Word)	WJBC-6-324.doc
Manuscript File	16502-Review.doc
Answering Reviewers	16502-Answering reviewers.pdf
Audio Core Tip	16502-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16502-Conflict-of-interest statement.pdf
Copyright License Agreement	16502-Copyright assignment.pdf
Peer-review Report	16502-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16502-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16502-Scientific misconduct check.pdf
Scientific Editor Work List	16502-Scientific editor work list.pdf