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Articles Published Processes
6/25/2015 3:27:00 PM | Browse: 1009 | Download: 1749
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Received |
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2015-01-21 09:17 |
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Peer-Review Started |
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2015-01-21 13:30 |
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To Make the First Decision |
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2015-02-07 14:57 |
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Return for Revision |
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2015-02-10 16:37 |
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Revised |
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2015-02-20 23:29 |
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Second Decision |
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2015-04-10 18:21 |
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Accepted by Journal Editor-in-Chief |
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2015-04-11 10:15 |
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Accepted by Executive Editor-in-Chief |
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2015-04-20 14:47 |
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Articles in Press |
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2015-04-20 14:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-06-08 18:03 |
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Publish the Manuscript Online |
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2015-06-25 15:27 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Bone morphogenetic protein-4 and transforming growth factor-beta1 mechanisms in acute valvular response to supra-physiologic hemodynamic stresses
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling Sun and Philippe Sucosky |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| American Heart Association Scientist Development Grant |
11SDG7600103 |
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| Corresponding Author |
Philippe Sucosky, PhD, FAHA, Department of Aerospace and Mechanical Engineering, University of Notre Dame, 143 Multidisciplinary Research Building, Notre Dame, IN 46556-5637, United States. philippe.sucosky@nd.edu |
| Key Words |
Aortic valve; Fluid shear stress; Calcification; Bone morphogenetic protein; Transforming growth factor beta |
| Core Tip |
Although flow abnormalities have been shown to promote valvular pathogenesis in a bone morphogenetic protein-4 (BMP-4)- and transforming growth factor-beta1 (TGF-β1)-dependent manner, the mode of action of those molecules in response to fluid shear stress (FSS) abnormalities remains unknown. This ex vivo study aimed at isolating the role played by those cytokines in the acute response of porcine leaflets to supra-physiologic FSS magnitude/frequency. The study reveals that: (1) valvular endothelial activation is weakly regulated by BMP-4 in response to FSS abnormalities; (2) TGF-β1 silencing attenuates FSS-induced extracellular matrix degradation via MMP-9 downregulation; and (3) BMP-4 and TGF-β1 do not synergistically interact in response to FSS abnormalities. |
| Publish Date |
2015-06-25 15:27 |
| Citation |
Sun L, Sucosky P. Bone morphogenetic protein-4 and transforming growth factor-beta1 mechanisms in acute valvular response to supra-physiologic hemodynamic stresses. World J Cardiol 2015; 7(6): 331-343 |
| URL |
http://www.wjgnet.com/1949-8462/full/v7/i6/331.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v7.i6.331 |
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