Publication Name	World Journal of Hepatology
Manuscript ID	16518
Country	Brazil

Received	2015-01-21 08:21
Peer-Review Started	2015-01-25 21:24
To Make the First Decision	2015-02-07 14:56
Return for Revision	2015-02-10 16:41
Revised	2015-02-22 22:44
Second Decision	2015-04-01 15:32
Accepted by Journal Editor-in-Chief	2015-04-02 21:38
Accepted by Executive Editor-in-Chief	2015-04-14 16:20
Articles in Press	2015-04-14 16:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-30 16:38
Publish the Manuscript Online	2015-06-16 14:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Editorial
Article Title	Liver-first approach of colorectal cancer with synchronous hepatic metastases: A reverse strategy
Manuscript Source	Invited Manuscript
All Author List	Jaques Waisberg and Ivan Gregório Ivankovics
Funding Agency and Grant Number
Corresponding Author	Jaques Waisberg, MD, PhD, FACS, Professor, Head of the ABC Medical School, Department of Surgery, ABC Medical School, Avenida Príncipe de Gales 821, Santo André, São Paulo 09060-650, Brazil. jaqueswaisberg@uol.com.br
Key Words	Colorectal neoplasms; Neoplasm metastasis; Liver neoplasms; Liver/surgery; Hepatectomy; Drug therapy; Survival; Prognosis
Core Tip	The liver-first approach or reverse strategy is a downstaging regimen, and it consists of systemic chemotherapy, chemoradiotherapy and/or biological agents, followed by resection of colorectal hepatic metastases prior to removal the primary colorectal tumor. It is a promising strategy in patients with synchronous colorectal liver metastases. The rationale behind this liver-first strategy is initially control of synchronous hepatic metastases of colorectal carcinoma, which can optimize the opportunity of a potentially curative liver resection and longstanding survival. The liver-first strategy can be applied for patients with early stage colorectal carcinoma and synchronous hepatic metastases. Extensive or locally advanced rectal carcinoma with limited or advanced synchronous hepatic metastases and asymptomatic colonic carcinoma with extensive synchronous hepatic metastases may be submitted to the liver-first strategy.
Publish Date	2015-06-16 14:22
Citation	Waisberg J, Ivankovics IG. Liver-first approach of colorectal cancer with synchronous hepatic metastases: A reverse strategy. World J Hepatol 2015; 7(11): 1444-1449
URL	http://www.wjgnet.com/1948-5182/full/v7/i11/1444.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i11.1444

Full Article (PDF)	WJH-7-1444.pdf
Full Article (Word)	WJH-7-1444.doc
Manuscript File	16518-Review.docx
Answering Reviewers	16518-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	16518-Conflict-of-interest statement.pdf
Copyright License Agreement	16518-Copyright assignment.pdf
Peer-review Report	16518-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16518-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16518-Scientific misconduct check.pdf
Scientific Editor Work List	16518-Scientific editor work list.pdf