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6/18/2015 5:31:00 PM | Browse: 751 | Download: 897
Publication Name World Journal of Gastroenterology
Manuscript ID 16527
Country of Manuscript Source United Kingdom
Received
2015-01-22 09:22
Peer-Review Started
2015-01-22 09:52
To Make the First Decision
2015-03-10 19:19
Return for Revision
2015-03-17 11:32
Revised
2015-03-31 00:00
Second Decision
2015-05-04 08:32
Accepted by Journal Editor-in-Chief
2015-05-04 09:39
Accepted by Company Editor-in-Chief
2015-05-07 15:49
Articles in Press
2015-05-07 15:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-05-29 16:36
Publish the Manuscript Online
2015-06-18 17:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Topic Highlights
Article Title Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: an update
Manuscript Source Invited Manuscript
All Author List Vasilios G Athyros, Konstantinos Tziomalos, Niki Katsiki, Michael Doumas, Asterios Karagiannis and Dimitri P Mikhailidis
Funding Agency and Grant Number
Correspondence To Dimitri P Mikhailidis, MD, FFPM, FRCP, FRCPath, Academic Head, Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free Hospital Campus, University College London Medical School, University College London, Pond Street, London NW3 2QG, United Kingdom. mikhailidis@aol.com
Keywords Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Cardiovascular disease; Liver fibrosis; statins; Chronic kidney disease; Arterial stiffness; Inflammation
Core Tip Non-alcoholic fatty liver disease (NAFLD) is an independent cardiovascular disease (CVD) risk factor. However, simple steatosis has a rather benign clinical course, while its advanced form, non-alcoholic steatohepatitis (NASH) substantially increases total mortality, mainly due to increased CVD events. In this review we propose the use of statin treatment for NASH, given its beneficial effect on NAFLD/NASH and CVD risk. There are data suggesting biopsy proven amelioration of NASH and normalization in liver ultrasonography and enzyme values as well as improvement of chronic kidney disease and arterial stiffness that usually accompany NASH and exacerbate CVD risk.
Publish Date 2015-06-18 17:32
Citation Athyros VG, Tziomalos K, Katsiki N, Doumas M, Karagiannis A, Mikhailidis DP. Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: An update. World J Gastroenterol 2015; 21(22): 6820-6834
Url http://www.wjgnet.com/1007-9327/full/v21/i22/6820.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i22.6820
Full Article (PDF) WJG-21-6820.pdf
Full Article (Word) WJG-21-6820.doc
Manuscript File 16527-Review.doc
Answering Reviewers 16527-Answering reviewers.pdf
Audio Core Tip 16527-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16527-Conflict-of-interest statement.pdf
Copyright License Agreement 16527-Copyright assignment.pdf
Peer-review Report 16527-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16527-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16527-Scientific misconduct check.pdf
Scientific Editor Work List 16527-Scientific editor work list.pdf