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Articles Published Processes
6/18/2015 5:31:00 PM | Browse: 1595 | Download: 2125
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Received |
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2015-01-22 09:22 |
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Peer-Review Started |
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2015-01-22 09:52 |
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To Make the First Decision |
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2015-03-10 19:19 |
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Return for Revision |
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2015-03-17 11:32 |
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Revised |
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2015-03-31 00:00 |
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Second Decision |
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2015-05-04 08:32 |
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Accepted by Journal Editor-in-Chief |
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2015-05-04 09:39 |
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Accepted by Executive Editor-in-Chief |
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2015-05-07 15:49 |
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Articles in Press |
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2015-05-07 15:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-05-29 16:36 |
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Publish the Manuscript Online |
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2015-06-18 17:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: an update
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vasilios G Athyros, Konstantinos Tziomalos, Niki Katsiki, Michael Doumas, Asterios Karagiannis and Dimitri P Mikhailidis |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dimitri P Mikhailidis, MD, FFPM, FRCP, FRCPath, Academic Head, Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free Hospital Campus, University College London Medical School, University College London, Pond Street, London NW3 2QG, United Kingdom. mikhailidis@aol.com |
| Key Words |
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Cardiovascular disease; Liver fibrosis; statins; Chronic kidney disease; Arterial stiffness; Inflammation |
| Core Tip |
Non-alcoholic fatty liver disease (NAFLD) is an independent cardiovascular disease (CVD) risk factor. However, simple steatosis has a rather benign clinical course, while its advanced form, non-alcoholic steatohepatitis (NASH) substantially increases total mortality, mainly due to increased CVD events. In this review we propose the use of statin treatment for NASH, given its beneficial effect on NAFLD/NASH and CVD risk. There are data suggesting biopsy proven amelioration of NASH and normalization in liver ultrasonography and enzyme values as well as improvement of chronic kidney disease and arterial stiffness that usually accompany NASH and exacerbate CVD risk. |
| Publish Date |
2015-06-18 17:32 |
| Citation |
Athyros VG, Tziomalos K, Katsiki N, Doumas M, Karagiannis A, Mikhailidis DP. Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: An update. World J Gastroenterol 2015; 21(22): 6820-6834 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i22/6820.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i22.6820 |
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