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Articles Published Processes
8/8/2015 3:25:00 PM | Browse: 1129 | Download: 2539
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Received |
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2015-01-27 09:49 |
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Peer-Review Started |
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2015-01-29 08:13 |
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To Make the First Decision |
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2015-06-02 13:19 |
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Return for Revision |
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2015-06-05 17:16 |
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Revised |
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2015-06-18 01:11 |
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Second Decision |
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2015-06-26 09:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-07-03 16:50 |
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Articles in Press |
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2015-07-03 16:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-07-29 11:48 |
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Publish the Manuscript Online |
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2015-08-08 15:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anabel Brandoni and Adriana Mónica Torres |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondo para la Investigación Científica y Tecnológica |
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| Consejo Nacional de Investigaciones Científicas y Técnicas |
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| Universidad Nacional de Rosario |
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| Corresponding Author |
Adriana Mónica Torres, PhD, Professor of Pharmacology, Pharmacology, Department of Physiological Sciences, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, CONICET, Suipacha 531, Rosario 2000, Argentina. admotorres@yahoo.com.ar |
| Key Words |
Cholestasis; Kidney; Transporters; Organic anions |
| Core Tip |
Organic anion transporter 5 (Oat5) is an organic anion/dicarboxylate exchanger which has impact on renal excretion of hormones, drugs and xenobiotics. The primary function of sodium-dicarboxylate cotransporter 1 (NaDC1) is to reabsorb filtered Krebs cycle intermediates, such as citrate. We found upregulations of both transporters and a decrease in urinary citrate excretion in bile duct-ligated rats. Citrate excretion is decreased at least in part, because of the higher NaDC1 expression. Using the outward gradient of citrate generated by NaDC1, Oat5 can reabsorb/eliminate different organic anions of pathophysiological importance. Attention might be paid for those drugs transported by this protein because their pharmacokinetics may be altered during cholestasis. |
| Publish Date |
2015-08-08 15:26 |
| Citation |
Brandoni A, Torres AM. Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction. World J Gastroenterol 2015; 21(29): 8817-8825 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i29/8817.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i29.8817 |
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