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Publication Name World Journal of Gastroenterology
Manuscript ID 16533
Country/Territory Argentina
Received
2015-01-27 09:49
Peer-Review Started
2015-01-29 08:13
To Make the First Decision
2015-06-02 13:19
Return for Revision
2015-06-05 17:16
Revised
2015-06-18 01:11
Second Decision
2015-06-26 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-07-03 16:50
Articles in Press
2015-07-03 16:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-07-29 11:48
Publish the Manuscript Online
2015-08-08 15:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction
Manuscript Source Invited Manuscript
All Author List Anabel Brandoni and Adriana Mónica Torres
Funding Agency and Grant Number
Funding Agency Grant Number
Fondo para la Investigación Científica y Tecnológica
Consejo Nacional de Investigaciones Científicas y Técnicas
Universidad Nacional de Rosario
Corresponding Author Adriana Mónica Torres, PhD, Professor of Pharmacology, Pharmacology, Department of Physiological Sciences, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, CONICET, Suipacha 531, Rosario 2000, Argentina. admotorres@yahoo.com.ar
Key Words Cholestasis; Kidney; Transporters; Organic anions
Core Tip Organic anion transporter 5 (Oat5) is an organic anion/dicarboxylate exchanger which has impact on renal excretion of hormones, drugs and xenobiotics. The primary function of sodium-dicarboxylate cotransporter 1 (NaDC1) is to reabsorb filtered Krebs cycle intermediates, such as citrate. We found upregulations of both transporters and a decrease in urinary citrate excretion in bile duct-ligated rats. Citrate excretion is decreased at least in part, because of the higher NaDC1 expression. Using the outward gradient of citrate generated by NaDC1, Oat5 can reabsorb/eliminate different organic anions of pathophysiological importance. Attention might be paid for those drugs transported by this protein because their pharmacokinetics may be altered during cholestasis.
Publish Date 2015-08-08 15:26
Citation Brandoni A, Torres AM. Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction. World J Gastroenterol 2015; 21(29): 8817-8825
URL http://www.wjgnet.com/1007-9327/full/v21/i29/8817.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i29.8817
Full Article (PDF) WJG-21-8817.pdf
Full Article (Word) WJG-21-8817.doc
Manuscript File 16533-Review.doc
Answering Reviewers 16533-Answering reviewers.pdf
Audio Core Tip 16533-Audio core tip.mp3
Biostatistics Review Certificate 16533-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 16533-Conflict-of-interest statement.pdf
Copyright License Agreement 16533-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 16533-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 16533-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 16533-Language certificate.pdf
Scientific Misconduct Check 16533-Scientific misconduct check.pdf
Scientific Editor Work List 16533-Scientific editor work list.pdf