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Articles Published Processes
12/10/2015 10:17:00 AM | Browse: 1032 | Download: 2011
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Received |
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2015-01-22 21:01 |
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Peer-Review Started |
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2015-01-24 08:24 |
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To Make the First Decision |
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2015-04-13 15:54 |
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Return for Revision |
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2015-04-14 10:32 |
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Revised |
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2015-04-23 15:33 |
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Second Decision |
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2015-08-10 08:25 |
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Accepted by Journal Editor-in-Chief |
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2015-08-10 15:00 |
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Accepted by Executive Editor-in-Chief |
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2015-08-25 16:53 |
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Articles in Press |
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2015-08-25 16:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-09-21 07:18 |
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Typeset the Manuscript |
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2015-09-25 14:36 |
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Publish the Manuscript Online |
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2015-10-19 09:14 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatic differentiation of rat induced pluripotent stem cells in vitro
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chao Sun, Jun-Jie Hu, Qin Pan, Yi Cao, Jian-Gao Fan and Guang-Ming Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81000173 |
| National Natural Science Foundation of China |
81070344 |
| National Natural Science Foundation of China |
81100297 |
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| Corresponding Author |
Guang-Ming Li, MD, PhD, Department of Gastroenterology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. ligm55@163.com |
| Key Words |
Hepatic differentiation; Induced pluripotent stem cells; Hepatocyte-like cells; Rat |
| Core Tip |
Induced pluripotent stem cells (iPSCs) can differentiate into many kinds of cells, including hepatocytes. However, the most important animal model for studying human diseases, especially liver diseases, is the rat model. This study is the first to show the efficient generation of hepatocyte-like cells (HLCs) differentiated from the iPSCs of rats. Hepatic differentiation was achieved using a three-step protocol. Rat iPSCs were differentiated into HLCs after 20 d of culture. These differentiated cells expressed hepatic markers and exhibited functional hepatic characteristics. These differentiated cells may be an attractive resource for treatment of liver disease. |
| Publish Date |
2015-10-19 09:14 |
| Citation |
Sun C, Hu JJ, Pan Q, Cao Y, Fan JG, Li GM. Hepatic differentiation of rat induced pluripotent stem cells in vitro. World J Gastroenterol 2015; 21(39): 11118-11126 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i39/11118.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i39.11118 |
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