Publication Name	World Journal of Gastroenterology
Manuscript ID	16550
Country	Japan

Received	2015-01-22 21:00
Peer-Review Started	2015-01-24 08:34
To Make the First Decision	2015-02-10 15:30
Return for Revision	2015-02-12 14:32
Revised	2015-02-24 08:26
Second Decision	2015-04-22 08:03
Accepted by Journal Editor-in-Chief	2015-04-22 20:35
Accepted by Executive Editor-in-Chief	2015-05-04 18:13
Articles in Press	2015-05-04 18:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-15 10:11
Publish the Manuscript Online	2015-06-29 16:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Nanoscience & Nanotechnology
Manuscript Type	Topic Highlights
Article Title	Applications of human hepatitis B virus preS domain in bio- and nanotechnology
Manuscript Source	Invited Manuscript
All Author List	Riki Toita, Takahito Kawano, Jeong-Hun Kang and Masaharu Murata
Funding Agency and Grant Number	Funding Agency Grant Number Health Labour Sciences Research Grant Health Labour Sciences Research Grant Scientific Research 24300172 Scientific Research for Young-Scientists 25750176 Fukuoka Foundation for Sound Health Cancer Research Fund
Corresponding Author	Masaharu Murata, Professor, Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. m-murata@dem.med.kyushu-u.ac.jp
Key Words	Hepatitis B virus; Hepatocyte; delivery system; Vaccine; Hepatitis B surface antigen; Diagnosis
Core Tip	The hepatitis B surface antigen (HBsAg) of human hepatitis B virus (HBV) contains the large (L), middle (M), and small (S) surface proteins. The L protein consists of the S protein, preS1, and preS2. In HBsAg, the preS domain (preS1 + preS2) plays a key role in the infection of hepatocytic cells by HBV and has several immunogenic epitopes. Therefore, the preS domain can act as a diagnostic or therapeutic target or as material for developing inhibitors of HBV infection, HBV vaccines, diagnostic tools for HBV infection, and hepatocyte-targeting delivery systems for diagnostic or therapeutic molecules.
Publish Date	2015-06-29 16:33
Citation	Toita R, Kawano T, Kang JH, Murata M. Applications of human hepatitis B virus preS domain in bio- and nanotechnology. World J Gastroenterol 2015; 21(24): 7400-7411
URL	http://www.wjgnet.com/1007-9327/full/v21/i24/7400.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i24.7400

Full Article (PDF)	WJG-21-7400.pdf
Full Article (Word)	WJG-21-7400.doc
Manuscript File	16550-Review.docx
Answering Reviewers	16550-Answering reviewers.pdf
Audio Core Tip	16550-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16550-Conflict-of-interest statement.pdf
Copyright License Agreement	16550-Copyright assignment.pdf
Peer-review Report	16550-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16550-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16550-Scientific misconduct check.pdf
Scientific Editor Work List	16550-Scientific editor work list.pdf