Publication Name	World Journal of Gastroenterology
Manuscript ID	16558
Country	Italy

Received	2015-01-23 08:46
Peer-Review Started	2015-01-24 11:07
To Make the First Decision	2015-03-10 19:50
Return for Revision	2015-03-17 11:30
Revised	2015-03-31 18:27
Second Decision	2015-05-04 08:30
Accepted by Journal Editor-in-Chief	2015-05-07 23:18
Accepted by Executive Editor-in-Chief	2015-05-21 17:40
Articles in Press	2015-05-21 17:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-22 19:32
Typeset the Manuscript	2015-06-12 13:42
Publish the Manuscript Online	2015-06-29 16:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Losurdo, Domenico Piscitelli, Antonio Giangaspero, Mariabeatrice Principi, Francesca Buffelli, Floriana Giorgio, Lucia Montenegro, Claudia Sorrentino, Annacinzia Amoruso, Enzo Ierardi and Alfredo Di Leo
Funding Agency and Grant Number
Corresponding Author	Enzo Ierardi, Professor, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy. ierardi.enzo@gmail.com
Key Words	Duodenal lymphocytosis; Celiac disease; Gluten sensitivity; Seronegative celiac disease; Intraepithelial lymphocytes; Immunohistochemistry
Core Tip	Duodenal lymphocytosis may pose a diagnostic challenge since it could be associated with different pathological conditions, which may or may not be related to gluten. In the present study, we demonstrated that during 2 years of follow-up of 85 patients with duodenal lymphocytosis, 27% developed celiac disease and 22% had a clinical diagnosis of gluten sensitivity; the remaining patients were affected by non-gluten-related conditions. At multivariate analysis, the haplotype DQ2/8 and the density of the intraepithelial CD3 lymphocyte infiltrate were the best predictors of the future development of gluten-related disorders.
Publish Date	2015-06-29 16:33
Citation	Losurdo G, Piscitelli D, Giangaspero A, Principi M, Buffelli F, Giorgio F, Montenegro L, Sorrentino C, Amoruso A, Ierardi E, Di Leo A. Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up. World J Gastroenterol 2015; 21(24): 7545-7552
URL	http://www.wjgnet.com/1007-9327/full/v21/i24/7545.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i24.7545

Full Article (PDF)	WJG-21-7545.pdf
Full Article (Word)	WJG-21-7545.doc
Manuscript File	16558-Review.doc
Answering Reviewers	16558-Answering reviewers.pdf
Audio Core Tip	16558-Audio core tip.mp3
Biostatistics Review Certificate	16558-Biostatistics statement.pdf
Clinical Trial Registration Statement	16558-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	16558-Conflict-of-interest statement.pdf
Copyright License Agreement	16558-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	16558-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	16558-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	16558-Language certificate.pdf
Peer-review Report	16558-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16558-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16558-Scientific misconduct check.pdf
Scientific Editor Work List	16558-Scientific editor work list.pdf