Publication Name	World Journal of Gastroenterology
Manuscript ID	16571
Country	Japan

Received	2015-01-23 19:25
Peer-Review Started	2015-01-24 21:26
To Make the First Decision	2015-03-10 19:51
Return for Revision	2015-03-17 11:29
Revised	2015-03-24 15:22
Second Decision	2015-04-13 16:22
Accepted by Journal Editor-in-Chief	2015-04-14 23:02
Accepted by Executive Editor-in-Chief	2015-04-17 15:27
Articles in Press	2015-04-17 16:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-26 20:00
Publish the Manuscript Online	2015-06-18 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	What are the effects of proton pump inhibitors on the small intestine?
Manuscript Source	Invited Manuscript
All Author List	Shunji Fujimori
Funding Agency and Grant Number
Corresponding Author	Shunji Fujimori, MD, PhD, Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. s-fujimori@nms.ac.jp
Key Words	Proton-pump inhibitors; Nonsteroidal anti-inflammatory drug; Small intestine; Dysbiosis; Small intestinal bacterial overgrowth
Core Tip	Proton-pump inhibitor (PPI) administration provokes dysbiosis of small intestinal bacterial flora, which exacerbates nonsteroidal anti-inflammatory drug-induced small intestinal injury. Dysbiosis is considered part of small intestinal bacterial overgrowth. Both PPI administration and gastrectomy increase the frequency of small intestinal bacterial overgrowth. Intestinal bacterial flora influence a number of systematic diseases. The influence of acid suppression therapy, especially PPIs, on small intestinal bacterial flora is worth noting.
Publish Date	2015-06-18 17:32
Citation	Fujimori S. What are the effects of proton pump inhibitors on the small intestine? World J Gastroenterol 2015; 21(22): 6817-6819
URL	http://www.wjgnet.com/1007-9327/full/v21/i22/6817.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i22.6817

Full Article (PDF)	WJG-21-6817.pdf
Full Article (Word)	WJG-21-6817.doc
Manuscript File	16571-Review.doc
Answering Reviewers	16571-Answering reviewers.pdf
Audio Core Tip	16571-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16571-Conflict-of-interest statement.pdf
Copyright License Agreement	16571-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	16571-Language certificate.pdf
Peer-review Report	16571-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16571-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16571-Scientific misconduct check.pdf
Scientific Editor Work List	16571-Scientific editor work list.pdf