Publication Name	World Journal of Cardiology
Manuscript ID	16577
Country	Germany

Received	2015-01-23 19:35
Peer-Review Started	2015-01-24 16:09
To Make the First Decision	2015-03-06 10:13
Return for Revision	2015-03-15 18:55
Revised	2015-03-23 18:23
Second Decision	2015-05-08 17:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-05-18 17:16
Articles in Press	2015-05-18 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-14 19:17
Publish the Manuscript Online	2015-08-27 11:20

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Nanoscience & Nanotechnology
Manuscript Type	Editorial
Article Title	Thrombosis: Novel nanomedical concepts of diagnosis and treatment
Manuscript Source	Invited Manuscript
All Author List	Iwona Cicha
Funding Agency and Grant Number	Funding Agency Grant Number EU “NanoAthero” project FP7-NMP-2012-LARGE-6-30982 DFG CI 162/2-1, SPP1681
Corresponding Author	Dr. Iwona Cicha, PhD, Cardiovascular Nanomedicine Unit, Section of Experimental Oncology and Nanomedicine, ENT-Department, University Hospital Erlangen, Glückstr 10a, 91054 Erlangen, Germany. iwona.cicha@yahoo.com
Key Words	Thrombosis; Thrombus imaging; Nanome­dicine; Targeted nanoparticles; Thrombolytic drug-delivery systems
Core Tip	The prevalence of thrombosis, the formation of life-threatening clots obstructing vital blood vessels, continues to rise. Accurate diagnosis and rapid recanali-zation of an occluded artery is essential to improve outcomes and reduce the mortality in acute myocardial infarction or stroke. The current thrombo-lytic therapy often fails to diminish the occlusion and is associated with a high rate of hemorrhagic complications. Develop-ment of directed nanosystems for local thrombolysis, characterized by a strong fibrinolytic effect and low bleeding risk, is therefore one of the most urgent tasks in the prevention and the therapy of acute thrombotic events.
Publish Date	2015-08-27 11:20
Citation	Cicha I. Thrombosis: Novel nanomedical concepts of diagnosis and treatment. World J Cardiol 2015; 7(8): 434-441
URL	http://www.wjgnet.com/1949-8462/full/v7/i8/434.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i8.434

Full Article (PDF)	WJC-7-434.pdf
Full Article (Word)	WJC-7-434.doc
Manuscript File	16577-Review.docx
Answering Reviewers	16577-Answering reviewers.pdf
Audio Core Tip	16577-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16577-Conflict-of-interest statement.pdf
Copyright License Agreement	16577-Copyright assignment.pdf
Peer-review Report	16577-Peer-review(s).pdf
Scientific Misconduct Check	16577-Scientific misconduct check.pdf
Scientific Editor Work List	16577-Scientific editor work list.pdf