Publication Name	World Journal of Pharmacology
Manuscript ID	16580
Country	Japan

Received	2015-01-23 18:19
Peer-Review Started	2015-01-24 09:49
To Make the First Decision	2015-02-07 14:55
Return for Revision	2015-02-10 17:12
Revised	2015-02-25 00:00
Second Decision	2015-03-16 18:12
Accepted by Journal Editor-in-Chief	2015-03-16 21:08
Accepted by Executive Editor-in-Chief	2015-04-07 16:09
Articles in Press	2015-04-07 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-01 16:01
Publish the Manuscript Online	2015-06-19 15:32

ISSN	2220-3192 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Allergy
Manuscript Type	Editorial
Article Title	Enhanced permeability and retention effect based nanomedicine, a solution for cancer
Manuscript Source	Invited Manuscript
All Author List	Jun Fang
Funding Agency and Grant Number
Corresponding Author	Jun Fang, MD, PhD, Associate Professor, Research Institute of Drug Delivery Science, Sojo University, Ikeda 4-22-1, Kumamoto 860-0082, Japan. fangjun@ph.sojo-u.ac.jp
Key Words	Enhanced permeability and retention effect; Tumor targeting; Nanomedicine; Cancer; Chemotherapy; Polymeric therapeutics; Macromolecular drugs
Core Tip	Current cancer chemotherapy is less effective with adverse side effects, mostly due to lack of tumor-selectivity. Thus tumor-targeting is known the key for successful chemotherapy. Molecular-target therapy is such a strategy but the clinical results are disappointing probably due to the diversity of cancer-related molecules and enormous mutations. A more general tumor-targeting strategy is based on the unique physiophathological and anatomical features of solid tumors - enhanced permeability and retention (EPR) effect. Accordingly nanomedicine has been developed, with promising therapeutic potential and very less side effects. We thus believe EPR-based nanomedicine will be a solution for cancer in the future.
Publish Date	2015-06-19 15:32
Citation	Fang J. Enhanced permeability and retention effect based nanomedicine, a solution for cancer. World J Pharmacol 2015; 4(2): 168-171
URL	http://www.wjgnet.com/2220-3192/full/v4/i2/168.htm
DOI	http://dx.doi.org/10.5497/wjp.v4.i2.168

Full Article (PDF)	WJP-4-168.pdf
Full Article (Word)	WJP-4-168.doc
Manuscript File	16580-Review.docx
Answering Reviewers	16580-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	16580-Conflict-of-interest statement.pdf
Copyright License Agreement	16580-Copyright assignment.pdf
Peer-review Report	16580-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16580-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16580-Scientific misconduct check.pdf
Scientific Editor Work List	16580-Scientific editor work list.pdf