| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qin Pan, Rui-Nan Zhang, Yu-Qin Wang, Rui-Dan Zheng, Yu-Qiang Mi, Wen-Bin Liu, Feng Shen, Guang-Yu Chen, Jia-Fa Lu, Chan-Yan Zhu, Shu-Yi Zhang, Yi-Ming Chen, Wan-Lu Sun and Jian-Gao Fan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| State Key Development Program for Basic Research of China |
2012CB517501 |
| National Natural Science Foundation of China |
81070322 |
| National Natural Science Foundation of China |
81270491 |
| National Natural Science Foundation of China |
81470840 |
| 100 Talents Program |
XBR2011007h |
| Program of the Shanghai Committee of Science and Technology |
09140903500 |
| Program of the Shanghai Committee of Science and Technology |
13ZR14267 |
|
| Corresponding Author |
Jian-Gao Fan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. fattyliver2004@126.com |
| Key Words |
Chronic hepatitis B; Hepatitis B virus; Nonalcoholic fatty liver disease; PNPLA3; Single-nucleotide polymorphism |
| Core Tip |
The association of PNPLA3 polymorphisms with concurrent chronic hepatitis B and nonalcoholic fatty liver disease was determined in Chinese Han patients. The effect of PNPLA3 genotypes on hepatitis B virus load was also evaluated. Four linked single-nucleotide polymorphisms of PNPLA3 (rs738409 G allele, rs3747206 T allele, rs4823173 A allele, and rs2072906 G allele) conferred susceptibility to nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and liver fibrosis in chronic hepatitis B patients. Patients carrying these single-nucleotide polymorphisms showed a significantly lower serum level of hepatitis B virus DNA. |
| Publish Date |
2015-07-30 11:17 |
| Citation |
Pan Q, Zhang RN, Wang YQ, Zheng RD, Mi YQ, Liu WB, Shen F, Chen GY, Lu JF, Zhu CY, Zhang SY, Chen YM, Sun WL, Fan JG. Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B. World J Gastroenterol 2015; 21(28): 8605-8614 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i28/8605.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i28.8605 |
