Publication Name	World Journal of Biological Chemistry
Manuscript ID	16597
Country	United States

Received	2015-01-24 20:45
Peer-Review Started	2015-01-28 17:56
To Make the First Decision	2015-03-06 10:12
Return for Revision	2015-03-11 17:55
Revised	2015-03-25 06:30
Second Decision	2015-06-01 14:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-06-11 16:06
Articles in Press	2015-06-11 16:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-12 11:20
Publish the Manuscript Online	2015-08-26 11:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis
Manuscript Source	Invited Manuscript
All Author List	Kazim Husain, Edu Suarez, Angel Isidro, Wilfredo Hernandez and Leon Ferder
Funding Agency and Grant Number	Funding Agency Grant Number Abbott Pharmaceutical, United States
Corresponding Author	Kazim Husain, PhD, DABT, Professor, Department of Physiology, Pharmacology and Toxicology, Ponce School of Medicine and Health Sciences, PO Box 7004, Ponce, PR 00732, United States. khusain@psm.edu
Key Words	Atherosclerosis; Enalapril; Paricalcitol; Renal inflammation; Oxidative stress
Core Tip	Although the protective efficacy of vitamin D and angiotensin converting enzyme inhibitors (ACEIs) have been studied in the cardiovascular system of atherosclerotic mice. However this is the first report to investigate the renal protection by paricalcitol and enalapril, alone or in combination in ApoE-deficient atherosclerotic mice. This innovative study clearly shows that vitamin D, ACEI and their combo ameliorated the renal inflammation and oxidative stress in ApoE-knock out animals by depleting the inflammatory and oxidative stress markers as well as restoring the renal antioxidant defense system in atherosclerotic mice. The combination of paricalcitol and enalapril warrants the clinical usefulness in renal atherosclerotic patients.
Publish Date	2015-08-26 11:07
Citation	Husain K, Suarez E, Isidro A, Hernandez W, Ferder L. Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis. World J Biol Chem 2015; 6(3): 240-248
URL	http://www.wjgnet.com/1949-8454/full/v6/i3/240.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i3.240

Full Article (PDF)	WJBC-6-240.pdf
Full Article (Word)	WJBC-6-240.doc
Manuscript File	16597-Review.doc
Answering Reviewers	16597-Answering reviewers.pdf
Audio Core Tip	16597-Audio core tip.mp3
Biostatistics Review Certificate	16597-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16597-Conflict-of-interest statement.pdf
Copyright License Agreement	16597-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	16597-Institutional animal care and use committee statement.pdf
Peer-review Report	16597-Peer-review(s).pdf
Scientific Misconduct Check	16597-Scientific misconduct check.pdf
Scientific Editor Work List	16597-Scientific editor work list.pdf