Publication Name	World Journal of Gastroenterology
Manuscript ID	16606
Country	China

Received	2015-01-24 20:59
Peer-Review Started	2015-01-25 15:27
To Make the First Decision	2015-02-10 15:30
Return for Revision	2015-02-12 14:36
Revised	2015-03-09 00:00
Second Decision	2015-04-13 16:20
Accepted by Journal Editor-in-Chief	2015-04-13 20:03
Accepted by Company Editor-in-Chief	2015-04-17 15:36
Articles in Press	2015-04-17 16:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-08 06:28
Typeset the Manuscript	2015-07-01 15:16
Publish the Manuscript Online	2015-07-22 13:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Apoptosis of human pancreatic carcinoma cell line-1 cells induced by Yin Chen Hao Decoction
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Bo Zhou, Jing-Ming Chen, Li-Ming Shao and Zhi-Gang Chen
Funding Agency and Grant Number	Funding Agency Grant Number Traditional Chinese Medicine Administration of Zhejiang Province, China 2014ZA068
Corresponding Author	Hai-Bo Zhou, MD, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zhouhaibohz@163.com
Key Words	Yin Chen Hao Decoction; Pancreatic carcinoma; Apoptosis
Core Tip	Yin Chen Hao Decoction (YCHD) inhibited the growth of pancreatic carcinoma PANC-1 cells. Following treatment with YCHD for 24-96 h, the apoptotic rates in these cells were increased; the positive rate of Bcl-2 proteins and mRNA reduced; and the positive rate of Bax proteins and Bax mRNA increased. YCHD induced apoptosis of pancreatic carcinoma PANC-1 cells. Apoptosis of these cells may be mediated by up-regulation of the expression of Bax gene and down-regulation of the expression of Bcl-2 gene.
Publish Date	2015-07-22 13:58
Citation	Zhou HB, Chen JM, Shao LM, Chen ZG. Apoptosis of human pancreatic carcinoma cell-1 cells induced by Yin Chen Hao Decoction. World J Gastroenterol 2015; 21(27): 8352-8357
URL	http://www.wjgnet.com/1007-9327/full/v21/i27/8352.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i27.8352

Full Article (PDF)	WJG-21-8352.pdf
Full Article (Word)	WJG-21-8352.doc
Manuscript File	16606-Review.doc
Answering Reviewers	16606-Answering reviewers.pdf
Audio Core Tip	16606-Audio core tip.mp3
Biostatistics Review Certificate	16606-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16606-Conflict-of-interest statement.pdf
Copyright License Agreement	16606-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	16606-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	16606-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	16606-Language certificate.PDF
Peer-review Report	16606-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16606-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16606-Scientific misconduct check.pdf
Scientific Editor Work List	16606-Scientific editor work list.pdf