Publication Name	World Journal of Radiology
Manuscript ID	16636
Country	Italy

Received	2015-01-26 09:12
Peer-Review Started	2015-01-26 11:58
To Make the First Decision	2015-03-06 10:10
Return for Revision	2015-03-15 18:22
Revised	2015-03-24 17:12
Second Decision	2015-10-10 17:59
Accepted by Journal Editor-in-Chief	2015-10-13 03:59
Accepted by Executive Editor-in-Chief	2015-11-04 17:27
Articles in Press	2015-11-04 17:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-22 21:06
Publish the Manuscript Online	2015-12-28 08:56

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Observational Study
Article Title	Combined value of apparent diffusion coefficient-standardized uptake value max in evaluation of post-treated locally advanced rectal cancer
Manuscript Source	Invited Manuscript
All Author List	Davide Ippolito, Davide Fior, Chiara Trattenero, Elena De Ponti, Silvia Drago, Luca Guerra, Cammillo Talei Franzesi and Sandro Sironi
Funding Agency and Grant Number
Corresponding Author	Davide Ippolito, MD, Department of Diagnostic Radiology, H S.Gerardo Monza, Via Pergolesi 11, 20052 Milan, Italy. davide.atena@tiscalinet.it
Key Words	Advanced rectal cancer; Functional imaging; FDG-PET/CT; Magnetic resonance imaging; Apparent diffusion coefficient; Neoadjuvant treatment; Tumor regression grade
Core Tip	In our study we evaluated the combination of changes of glucose metabolism values expressed as SUVmax and the changes of apparent diffusion coefficient (ADC map) values, before and after neoad-juvant therapy, in patients with advanced rectal cancer in order to predict, in vivo, the therapy response. The importance of this work consist of the possibility to offer, in the era of positron emission tomography (PET)/magnetic resonance imaging scanner, a new advanced tool that allows the non-invasive evaluation of response to neoadjuvant chemotherapy treatment in patients with rectal cancer, by adding quantitative value information on diffusion weighted images and on PET/computed tomography imaging.
Publish Date	2015-12-28 08:56
Citation	Ippolito D, Fior D, Trattenero C, De Ponti E, Drago S, Guerra L, Franzesi CT, Sironi S. Combined value of apparent diffusion coefficient-standardized uptake value max in evaluation of post-treated locally advanced rectal cancer. World J Radiol 2015; 7(12): 509-520
URL	http://www.wjgnet.com/1949-8470/full/v7/i12/509.htm
DOI	http://dx.doi.org/10.4329/wjr.v7.i12.509

Full Article (PDF)	WJR-7-509.pdf
Full Article (Word)	WJR-7-509.doc
Manuscript File	16636-Review.doc
Answering Reviewers	16636-Answering reviewers.pdf
Audio Core Tip	16636-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	16636-Conflict-of-interest statement.pdf
Copyright License Agreement	16636-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	16636-Institutional review board statement.pdf
Peer-review Report	16636-Peer-review(s).pdf
Scientific Misconduct Check	16636-Scientific misconduct check.pdf
Scientific Editor Work List	16636-Scientific editor work list.pdf