Publication Name	World Journal of Gastroenterology
Manuscript ID	16663
Country	China

Received	2015-01-27 09:24
Peer-Review Started	2015-01-27 09:58
To Make the First Decision	2015-03-10 17:54
Return for Revision	2015-03-12 10:35
Revised	2015-03-19 22:09
Second Decision	2015-04-24 10:36
Accepted by Journal Editor-in-Chief	2015-04-24 12:40
Accepted by Executive Editor-in-Chief	2015-05-04 17:23
Articles in Press	2015-05-04 17:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-06-10 11:02
Typeset the Manuscript	2015-07-06 09:38
Publish the Manuscript Online	2015-07-22 13:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Li Wang, Shuai Gao, Xin-You Li, Feng-Kai Sun, Feng Li, Yu-Chen Fan and Kai Wang
Funding Agency and Grant Number	Funding Agency Grant Number Key Project of Chinese Ministry of Science and Technology 2012ZX10002007 Key Project of Chinese Ministry of Science and Technology 2013ZX10002001 National Natural Science Foundation of China 81171579 National Natural Science Foundation of China 81201287 National Natural Science Foundation of China 81371832 Science and Technology Development Plan of Shandong Province, China 2014GSF118068
Corresponding Author	Kai Wang, MD, PhD, Department of Hepatology, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan 250012, Shandong Province, China. wangdoc876@126.com
Key Words	Tumor necrosis factor-α converting enzyme; Methylation; Chronic hepatitis B; Methylation-specific polymerase chain reaction; Biomarker
Core Tip	We retrospectively recruited 80 patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB), 80 with HBeAg-negative CHB, and 40 healthy controls. We evaluated tumor necrosis factor-α converting enzyme (TACE) promoter methylation status in peripheral blood mononuclear cells and analyzed the association between TACE methylation status and clinical features. Aberrant demethylation of TACE promoter in HBeAg-positive CHB was associated with high HBeAg, alanine aminotransferase and aspartate aminotransferase levels. These findings imply that demethylation of TACE promoter might potentially serve as a biomarker for HBeAg seroconversion.
Publish Date	2015-07-22 13:58
Citation	Wang ZL, Gao S, Li XY, Sun FK, Li F, Fan YC, Wang K. Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B. World J Gastroenterol 2015; 21(27): 8382-8388
URL	http://www.wjgnet.com/1007-9327/full/v21/i27/8382.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i27.8382

Full Article (PDF)	WJG-21-8382.pdf
Full Article (Word)	WJG-21-8382.doc
Manuscript File	16663-Review.docx
Answering Reviewers	16663-Answering reviewers.pdf
Audio Core Tip	16663-Audio core tip.mp3
Biostatistics Review Certificate	16663-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16663-Conflict of interest statement.pdf
Copyright License Agreement	16663-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150126200315.docx
Institutional Review Board Approval Form or Document	16663-Institutional Review Board statement.pdf
Non-Native Speakers of English Editing Certificate	16663-Language certificate.PDF
Peer-review Report	16663-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16663-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16663-Scientific misconduct check.pdf
Scientific Editor Work List	16663-Scientific editor work list.pdf