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Articles Published Processes
7/22/2015 2:02:00 PM | Browse: 1239 | Download: 2633
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Received |
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2015-01-27 09:24 |
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Peer-Review Started |
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2015-01-27 09:58 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-03-12 10:35 |
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Revised |
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2015-03-19 22:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-04-24 10:36 |
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Second Decision by Editor-in-Chief |
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2015-04-24 12:40 |
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Final Decision by Editorial Office Director |
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2015-05-04 17:23 |
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Articles in Press |
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2015-05-04 17:23 |
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Edit the Manuscript by Language Editor |
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2015-06-10 11:02 |
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Typeset the Manuscript |
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2015-07-06 09:38 |
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Publish the Manuscript Online |
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2015-07-22 13:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Li Wang, Shuai Gao, Xin-You Li, Feng-Kai Sun, Feng Li, Yu-Chen Fan and Kai Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Project of Chinese Ministry of Science and Technology |
2012ZX10002007 |
| Key Project of Chinese Ministry of Science and Technology |
2013ZX10002001 |
| National Natural Science Foundation of China |
81171579 |
| National Natural Science Foundation of China |
81201287 |
| National Natural Science Foundation of China |
81371832 |
| Science and Technology Development Plan of Shandong Province, China |
2014GSF118068 |
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| Corresponding Author |
Kai Wang, MD, PhD, Department of Hepatology, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan 250012, Shandong Province, China. wangdoc876@126.com |
| Key Words |
Tumor necrosis factor-α converting enzyme; Methylation; Chronic hepatitis B; Methylation-specific polymerase chain reaction; Biomarker |
| Core Tip |
We retrospectively recruited 80 patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB), 80 with HBeAg-negative CHB, and 40 healthy controls. We evaluated tumor necrosis factor-α converting enzyme (TACE) promoter methylation status in peripheral blood mononuclear cells and analyzed the association between TACE methylation status and clinical features. Aberrant demethylation of TACE promoter in HBeAg-positive CHB was associated with high HBeAg, alanine aminotransferase and aspartate aminotransferase levels. These findings imply that demethylation of TACE promoter might potentially serve as a biomarker for HBeAg seroconversion. |
| Publish Date |
2015-07-22 13:58 |
| Citation |
Wang ZL, Gao S, Li XY, Sun FK, Li F, Fan YC, Wang K. Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B. World J Gastroenterol 2015; 21(27): 8382-8388 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i27/8382.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i27.8382 |
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