Publication Name	World Journal of Gastroenterology
Manuscript ID	16683
Country	Türkiye

Received	2015-01-27 08:35
Peer-Review Started	2015-01-27 09:25
To Make the First Decision	2015-02-10 15:52
Return for Revision	2015-02-13 11:24
Revised	2015-03-04 08:20
Second Decision	2015-04-10 11:51
Accepted by Journal Editor-in-Chief	2015-04-13 02:23
Accepted by Executive Editor-in-Chief	2015-04-17 15:51
Articles in Press	2015-04-17 16:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-21 07:58
Typeset the Manuscript	2015-06-02 18:38
Publish the Manuscript Online	2015-06-20 17:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Obstetrics & Gynecology
Manuscript Type	Minireviews
Article Title	Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy
Manuscript Source	Invited Manuscript
All Author List	Sebiha Ozkan, Yasin Ceylan, Orhan Veli Ozkan and Sule Yildirim
Funding Agency and Grant Number
Corresponding Author	Orhan Veli Ozkan, Associate Professor, Department of General Surgery, Faculty of Medicine, Sakarya University, Adnan Menderes Caddesi, Saglik Sokak No.193, Sakarya 54187, Turkey. veliorhan@hotmail.com
Key Words	Intrahepatic; Cholestasis; Pregnancy; Diagnosis; Management
Core Tip	Intrahepatic cholestasis of pregnancy (ICP) is a unique hepatic disorder in pregnancy characterized by pruritus, elevated liver enzymes and serum bile acids. It appears usually in the third trimester and dissolves rapidly after delivery. The incidence is variable between 0.1%-15.6% in different geographic regions of the world. Genetic, hormonal and environmental factors interact in the etiopathogenesis. A considerable incidence of perinatal morbidity-mortality makes it one of the most concerning obstetric entities for the obstetricians and critical care specialists. Timely diagnosis and expert multidisciplinary management of the pregnant women with ICP are mandatory to ensure a favorable maternal-fetal outcome.
Publish Date	2015-06-20 17:38
Citation	Ozkan S, Ceylan Y, Ozkan OV, Yildirim S. Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy. World J Gastroenterol 2015; 21(23): 7134-7141
URL	http://www.wjgnet.com/1007-9327/full/v21/i23/7134.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i23.7134

Full Article (PDF)	WJG-21-7134.pdf
Full Article (Word)	WJG-21-7134.doc
Manuscript File	16683-Review.docx
Answering Reviewers	16683-Answering reviewers.pdf
Audio Core Tip	16683-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	16683-Conflict-of-interest statement.pdf
Copyright License Agreement	16683-Copyright assignment.pdf
Peer-review Report	16683-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16683-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16683-Scientific misconduct check.pdf
Scientific Editor Work List	16683-Scientific editor work list.pdf