Publication Name	World Journal of Respirology
Manuscript ID	16711
Country	Türkiye

Received	2015-01-28 10:54
Peer-Review Started	2015-01-28 19:32
To Make the First Decision	2015-03-06 10:29
Return for Revision	2015-03-11 17:39
Revised	2015-04-13 16:11
Second Decision	2015-05-15 17:42
Accepted by Journal Editor-in-Chief	2015-05-17 18:06
Accepted by Executive Editor-in-Chief	2015-05-27 15:11
Articles in Press	2015-05-27 15:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-28 17:13
Typeset the Manuscript	2015-07-13 15:33
Publish the Manuscript Online	2015-08-04 12:43

ISSN	2218-6255 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Respiratory System
Manuscript Type	Editorial
Article Title	Causes of failure in acute respiratory distress syndrome modeling and treatment in animal research and new approaches
Manuscript Source	Invited Manuscript
All Author List	Emine Yilmaz Sipahi
Funding Agency and Grant Number
Corresponding Author	Emine Yilmaz Sipahi, MD, Professor, Department of Medical Pharmacology, Faculty of Medicine, Bulent Ecevit University, Kozlu, 67600 Zonguldak, Turkey. dresipahi@yahoo.com
Key Words	Acute respiratory distress syndrome; Lung injury; Animal models; Model limitations
Core Tip	Acute respiratory distress syndrome (ARDS) is a syndrome with multiple risk factors that trigger the acute onset of respiratory insufficiency. ARDS is still one of the most fatal diseases with a high mortality rate in intensive care units. Mortality rates remain unchanged, pharmacotherapies have a very limited role in the management of ARDS and additional treatments are sorely needed. Animal models provide a bridge between patients and the laboratory bench, but these models have certain limitations and to date, no single animal model reproduces all the characteristics of human ARDS. Despite these limitations, the complex pathogenesis of ARDS makes animal models necessary.
Publish Date	2015-08-04 12:43
Citation	Yilmaz Sipahi E. Causes of failure in acute respiratory distress syndrome modeling and treatment in animal research and new approaches. World J Respirol 2015; 5(2): 65-68
URL	http://www.wjgnet.com/2218-6255/full/v5/i2/65.htm
DOI	http://dx.doi.org/10.5320/wjr.v5.i2.65

Full Article (PDF)	WJR-5-65.pdf
Full Article (Word)	WJR-5-65.doc
Manuscript File	16711-Review.doc
Answering Reviewers	16711-Answering reviewers.pdf
Audio Core Tip	16711-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	16711-Conflict-of-interest statement.pdf
Copyright License Agreement	16711-Copyright assignment.pdf
Peer-review Report	16711-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16711-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16711-Scientific misconduct check.pdf
Scientific Editor Work List	16711-Scientific editor work list.pdf