Publication Name	World Journal of Translational Medicine
Manuscript ID	16712
Country	China

Received	2015-01-28 10:50
Peer-Review Started	2015-01-28 19:41
To Make the First Decision	2015-04-10 17:50
Return for Revision	2015-04-16 12:09
Revised	2015-04-27 11:32
Second Decision	2015-08-20 16:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-08-31 15:29
Articles in Press	2015-08-31 15:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-05 16:44
Typeset the Manuscript	2015-12-10 09:42
Publish the Manuscript Online	2015-12-15 17:37

ISSN	2220-6132 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pharmacology & Pharmacy
Manuscript Type	Minireviews
Article Title	Targeting apoptosis is the major battle field for killing cancers
Manuscript Source	Invited Manuscript
All Author List	Xiao-Chun Liu, Jiang-Ming Gao, Shan Liu, Li Liu, Jing-Rui Wang, Xian-Jun Qu, Bing Cai and Shu-Lin Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Key Sci-Tech Special Project of Ministry of Science and Technology of China 2008ZX10002-020 National Natural Science Foundation of China 30973390 National Natural Science Foundation of China 81272249 (to S. W)
Corresponding Author	Shu-Lin Wang, MD, PhD, Professor, the Marine Biomedical Research Institute of Qingdao, Department of Pharmacology, School of Medicine and Pharmacy, Ocean University of China, 23 Hongkong East Rd. Marine Biomedical Research Building, Qingdao 266071, Shandong Province, China. shulinwang@ouc.edu.cn
Key Words	Apoptosis; Chemotherapy; Drug targets; Drug resistance; Cancer; Translational medicine
Core Tip	Chemotherapy and radiotherapy are important approaches for cancer therapy and have prolonged the lifespan and reduced the mortality of cancer patients. But chemotherapy and radiotherapy induce apoptosis in both cancer and normal cells, therefore possessing severe toxic side effects. It appears quite important to develop the biological mechanism-based drugs that that can selectively kill tumor cells but not normal cells. Molecular targets in the apoptotic signaling pathways such as p53, TRAIL, and Bcl-2 have been identified, and molecularly targeting drugs for a variety of tumors based on these pathways are currently under development. Dissecting the genetic alterations in a particular tumor type and designing the rational drug combinations targeting different pathways can help achieve synergy in eradicating cancer cells and reversing drug resistance, and this holds great promise for the personalized treatment of cancer patients.
Publish Date	2015-12-15 17:37
Citation	Liu XC, Gao JM, Liu S, Liu L, Wang JR, Qu XJ, Cai B, Wang SL. Targeting apoptosis is the major battle field for killing cancers. World J Transl Med 2015; 4(3): 69-77
URL	http://www.wjgnet.com/2220-6132/full/v4/i3/69.htm
DOI	http://dx.doi.org/10.5528/wjtm.v4.i3.69

Full Article (PDF)	WJTM-4-69.pdf
Full Article (Word)	WJTM-4-69.doc
Manuscript File	16712-Review.doc
Answering Reviewers	16712-Answering reviewers.pdf
Audio Core Tip	16712-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16712-Conflict-of-interest statement.pdf
Copyright License Agreement	16712-Copyright assignment.pdf
Peer-review Report	16712-Peer-review(s).pdf
Scientific Misconduct Check	16712-Scientific misconduct check.pdf
Scientific Editor Work List	16712-Scientific editor work list.pdf