Publication Name	World Journal of Translational Medicine
Manuscript ID	16735
Country	United States

Received	2015-01-28 08:37
Peer-Review Started	2015-01-28 14:54
To Make the First Decision	2015-02-07 14:53
Return for Revision	2015-02-10 14:52
Revised	2015-03-03 05:22
Second Decision	2015-04-01 15:33
Accepted by Journal Editor-in-Chief	2015-04-02 04:40
Accepted by Executive Editor-in-Chief	2015-04-14 16:22
Articles in Press	2015-04-14 16:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-07 10:17
Publish the Manuscript Online	2015-08-14 18:19

ISSN	2220-6132 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Allergy
Manuscript Type	Editorial
Article Title	Component-resolved allergen testing: The new frontier
Manuscript Source	Invited Manuscript
All Author List	Matthew T Tallar and Mitchell H Grayson
Funding Agency and Grant Number	Funding Agency Grant Number Children’s Research Institute of the Children’s Hospital of Wisconsin Department of Pediatrics, Medical College of Wisconsin
Corresponding Author	Mitchell H Grayson, MD, Associate Professor, Section of Allergy and Clinical Immunology, Department of Pediatrics, Medical College of Wisconsin, MFRC Room 5068, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States. wheeze@allergist.com
Key Words	Component resolved diagnosis; Molecular allergy; IgE; Polysensitization; Immunotherapy; Venom allergy; Food allergy
Core Tip	Component-resolved allergen diagnostic testing is testing for specific allergenic proteins in a given allergen. This testing modality may revolutionize diagnostics and treatment of immediate hypersensitivity reactions. Several promising studies and allergen components have been described for patients with food allergy, venom allergy, and idiopathic anaphylaxis. Some appear to have clinical utility, such as ω-5 gliadin in evaluating wheat dependent, exercise induced anaphylaxis. Components for many of the relevant aeroallergens have been characterized; however, readily available allergen components for injection are lacking, and further research is needed before these practices can be recommended for widespread clinical use.
Publish Date	2015-08-14 18:19
Citation	Tallar MT, Grayson MH. Component-resolved allergen testing: The new frontier. World J Transl Med 2015; 4(2): 44-50
URL	http://www.wjgnet.com/2220-6132/full/v4/i2/44.htm
DOI	http://dx.doi.org/10.5528/wjtm.v4.i2.44

Full Article (PDF)	WJTM-4-44.pdf
Full Article (Word)	WJTM-4-44.doc
Manuscript File	16735-Review.docx
Answering Reviewers	16735-Answering reviewers.pdf
Audio Core Tip	16735-Audio core tip.wav
Conflict-of-Interest Disclosure Form	16735-Conflict-of-interest statement.pdf
Copyright License Agreement	16735-Copyright assignment.pdf
Peer-review Report	16735-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16735-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16735-Scientific misconduct check.pdf
Scientific Editor Work List	16735-Scientific editor work list.pdf