Publication Name	World Journal of Hepatology
Manuscript ID	16737
Country	United Kingdom

Received	2015-01-28 08:33
Peer-Review Started	2015-01-28 13:32
To Make the First Decision	2015-02-07 14:53
Return for Revision	2015-02-10 14:55
Revised	2015-02-17 00:00
Second Decision	2015-03-09 09:38
Accepted by Journal Editor-in-Chief	2015-03-09 16:21
Accepted by Executive Editor-in-Chief	2015-03-18 17:25
Articles in Press	2015-03-18 17:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-19 15:03
Publish the Manuscript Online	2015-05-01 19:01

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Editorial
Article Title	Role natural killer group 2D-ligand interactions in hepatitis B infection
Manuscript Source	Invited Manuscript
All Author List	Teresa Pollicino and Lemonica Koumbi
Funding Agency and Grant Number
Corresponding Author	Lemonica Koumbi, Research Fellow, Department of Medicine, Hepatology and Gastroenterology Section, Imperial College, St. Mary’s Campus, Norfolk Place, W2 1PG London, United Kingdom. lemonica.koumbi@gmail.com
Key Words	Hepatitis B virus; Natural killer group 2D receptor; Natural killer cells; MHC class I polypeptide-related chain A; Hepatocellular carcinoma
Core Tip	Hepatitis B virus (HBV) infection is the leading cause of liver disease and hepatocellular carcinoma (HCC) worldwide. HBV persistence involves complex interactions between the virus and the immune system of the host. Natural killer group 2D (NKG2D) is an activating receptor, expressed on natural killer (NK), NK T and CD8+ T cells. NKG2D-ligand interactions are critical in the establishment of chronicity and the development of liver injury and HCC. However, the exact mechanisms involved are still elusive. Here previous studies are discussed on how HBV modulates the NKG2D activity to result in viral clearance, susceptibility to liver injury and tumour evasion.
Publish Date	2015-05-01 19:01
Citation	Pollicino T, Koumbi L. Role natural killer group 2D-ligand interactions in hepatitis B infection. World J Hepatol 2015; 7(6): 819-824
URL	http://www.wjgnet.com/1948-5182/full/v7/i6/819.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i6.819

Full Article (PDF)	WJH-7-819.pdf
Full Article (Word)	WJH-7-819.doc
Manuscript File	16737-Review.docx
Answering Reviewers	16737-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	16737-Conflict-of-interest statement.pdf
Copyright License Agreement	16737-Copyright assignment.pdf
Peer-review Report	16737-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16737-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16737-Scientific misconduct check.pdf
Scientific Editor Work List	16737-Scientific editor work list.pdf